CD49e (Integrin alpha 5) Monoclonal Antibody (P1D6), PE, eBioscience™, Invitrogen™

Description

• Description: This P1D6 monoclonal antibody reacts with human CD49e, which is also known as integrin alpha 5
• Integrins constitute a family of cell surface receptors that mediate adhesion between cells or between a cell and the extracellular matrix
• These proteins are heterodimers consisting of two distinct subunits, alpha and beta
• Integrin alpha 5 is expressed on thymocytes, T cells, monocytes, platelets, as well as early and activated B cells
• Integrins are also expressed on non-hematopoietic and cancer cells
• Integrin-mediated adhesion is regulated by changes in ligand affinity (or activation), cell shape, and integrin clustering and diffusion
• Integrin alpha 5 undergoes post-translational cleavage in its extracellular domain to produce disulfide-linked light and heavy chains that associate with the common beta 1 subunit to form the fibronectin receptor
• Studies have demonstrated the involvement of this integrin in cell adhesion, signaling, and apoptosis
• The P1D6 monoclonal antibody has been reported to have blocking activity
• Crossblocking studies indicate that P1D6 and eBioSAM-1 recognize a similar epitope
• Applications Reported: This P1D6 antibody has been reported for use in flow cytometric analysis
• Applications Tested: This P1D6 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells
• This can be used at 5 μL (0.25 μg) per test
• The product of this gene belongs to the integrin alpha chain family
• Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain
• This gene encodes the integrin alpha 5 chain
• Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor
• In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.