CD119 (IFN gamma Receptor 1) Monoclonal Antibody (GIR-208 (GIR 208)), Biotin, eBioscience™, Invitrogen™

Description

• Description: The monoclonal antibody reacts with human CD119 also known as the IFN gamma receptor 1 (alpha chain)
• IFN gamma R1 is found in a complex with IFN gamma receptor beta and recognizes with high affinity IFN gamma
• Expression is ubiquitous but low, although some cell types, such as monocytes express higher levels
• The GIR-208 monoclonal antibody is blocked from binding when IFN gamma is bound to the receptor
• Applications Reported: This GIR-208 (GIR 208) antibody has been reported for use in flow cytometric analysis
• Applications Tested: This GIR-208 (GIR 208) antibody has been tested by flow cytometric analysis of normal human peripheral blood cells
• This can be used at less than or equal to 0.25 μg per test
• A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
• Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
• It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
• Filtration: 0.2 μm post-manufacturing filtered
• This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor
• Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2
• A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection
• In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection.