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14-033-937

CD33 Monoclonal Antibody (HIM3-4), eBioscience™, Invitrogen™

Manufacturer: Invitrogen

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Each of 1 14-033-937-Each-of-1 In Stock ₹ 1,17,388.32

14-033-937 - Each of 1

₹ 1,17,388.32

In Stock

Quantity

1

Base Price: ₹ 1,17,388.32

GST (18%): ₹ 21,129.898

Total Price: ₹ 1,38,518.218

Antigen

CD33

Classification

Monoclonal

Concentration

0.5 mg/mL

Formulation

PBS with 0.09% sodium azide; pH 7.2

Gene Accession No.

P20138

Gene Symbols

CD33

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

945

Content And Storage

4° C

Form

Liquid

Applications

Flow Cytometry

Clone

HIM3-4

Conjugate

Unconjugated

Gene

CD33

Gene Alias

CD33; CD33 antigen; CD33 antigen (gp67); CD33 molecule; CD33 molecule transcript; FLJ00391; gp67; Myeloid cell surface antigen CD33; p67; sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3; SIGLEC3; Siglec-3

Host Species

Mouse

Quantity

2 mg

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG1 κ

Description

  • Description: The HIM3-4 monoclonal antibody reacts with human CD33, a 67 kDa member of the sialoadhesion family
  • CD33 is expressed by myelomonocytic precursors, monocytes, mast cells, and granulocytes
  • Hematopoietic stem cells and lymphocytes do not express this antigen
  • CD33 plays a role in sialic-acid dependent cell adhesion
  • Applications Reported: The HIM3-4 antibody has been reported for use in flow cytometric analysis
  • Applications Tested: The HIM3-4 antibody has been tested by flow cytometric analysis of normal human peripheral blood cells
  • This can be used at less than or equal to 1 μg per test
  • A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
  • Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
  • It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
  • Purity: Greater than 90%, as determined by SDS-PAGE
  • Aggregation: Less than 10%, as determined by HPLC
  • Filtration: 0.2 μm post-manufacturing filtered
  • CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family
  • It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies, and these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface
  • CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia
  • Further, CD33 is found on granulocyte and macrophage precursors in the bone marrow, but is not on pluripotent stem cells
  • CD33 is also expressed on, and is a useful marker for, peripheral monocytes
  • CD33 is useful for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias
  • Diseases associated with CD43 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.

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Antigen:
CD33
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P20138
Gene Symbols:
CD33
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
945
Content And Storage:
4° C
Form:
Liquid
Applications:
Flow Cytometry
Clone:
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Conjugate:
Unconjugated
Gene:
CD33
Gene Alias:
CD33; CD33 antigen; CD33 antigen (gp67); CD33 molecule; CD33 molecule transcript; FLJ00391; gp67; Myeloid cell surface antigen CD33; p67; sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3; SIGLEC3; Siglec-3
Host Species:
Mouse
Quantity:
2 mg
Primary or Secondary:
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Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1 κ

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