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14-061-937

CD61 (Integrin beta 3) Monoclonal Antibody (VI-PL2), eBioscience™, Invitrogen™

Manufacturer: Invitrogen

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Pack Size SKU Availability Price
Each of 1 14-061-937-Each-of-1 In Stock ₹ 1,17,388.32

14-061-937 - Each of 1

₹ 1,17,388.32

In Stock

Quantity

1

Base Price: ₹ 1,17,388.32

GST (18%): ₹ 21,129.898

Total Price: ₹ 1,38,518.218

Antigen

CD61 (Integrin beta 3)

Classification

Monoclonal

Concentration

0.5 mg/mL

Formulation

PBS with 0.09% sodium azide; pH 7.2

Gene Accession No.

P05106

Gene Symbols

ITGB3

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

102117791, 3690, 403788, 717379

Content And Storage

4° C

Form

Liquid

Applications

Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Western Blot

Clone

VI-PL2

Conjugate

Unconjugated

Gene

ITGB3

Gene Alias

antigen CD61; BDPLT16; BDPLT2; beta3 integrin; CD61; EGK_08849; glycoprotein GPIIIa; glycoprotein IIIa; GP3A; GPIIIa; GT; INGRB3; integrin beta 3; integrin beta 3 (Cd61); integrin beta-3; integrin beta-3 subunit; integrin subunit beta 3; integrin, beta 3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); ITGB3; platelet glycoprotein IIIa; platelet glycoprotein IIIa integrin subunit beta 3; platelet gpIIIa; platelet membrane glycoprotein IIIa

Host Species

Mouse

Quantity

2 mg

Primary or Secondary

Primary

Target Species

Baboon, Canine, Cynomolgus Monkey, Human, Rhesus Monkey

Product Type

Antibody

Isotype

IgG1 κ

Description

  • The VI-PL2 MAb reacts with human CD61, also known as integrin beta 3 and GPIIIa
  • CD61 is a 90-110 kDa member of the beta integrin family expressed by a wide variety of cells, including leukocytes, platelets, endothelial and smooth muscle cells
  • CD61 binds non-covalently with the alpha integrins CD41 and CD51, to form the alpha IIb beta3 (CD41/CD61) and alpha v beta3 (CD51/CD61) complexes
  • These alpha beta heterodimers are capable of mediating a variety of cellular responses including adhesion, trafficking, proliferaton and differentiation
  • The CD41/CD61 integrin has been shown to be involved in platelet aggregation, and binds to fibrinogen, von Willebrand Factor (vWF) and fibronectin
  • The CD51/CD61 integrin binds to matrix proteins including vitronectin, fibronectin, vWF and fibrinogen, and has been shown to have a strong role in modulating the migration and survival of angiogenic endothelial cells
  • This VI-PL2 antibody has also been shown to crossreact with canine and several Non-human Primate species, including baboon, rhesus, and cynomologus monkey
  • CD61 (GPIIIa, ITGB3) is a glycoprotein found on megakaryocytes, platelets and their precursors
  • CD61 antigen plays a role in platelet aggregation and also as a receptor for fibrinogen, fibronectin, von Willebrand factor and vitronectrin
  • CD61 is a 105 kDa glycoprotein that associates with either the alpha 11b integrin (CD41) or the alpha V integrin (CD51) at the cell surface
  • CD61 is expressed on platelets and megakaryocytes in association with CD41, and on endothelial cells, monocytes, platelets and osteoclasts in association with CD51
  • CD61 is a receptor for fibrinogen, fibronectin, Von Willebrand Factor, vitronectin and thrombospondin
  • The CD61 protein product is composed of an alpha chain and a beta chain
  • A given chain may combine with multiple partners resulting in different integrins
  • CD61 is found along with the alpha IIb chain in platelets
  • Like other integrins, CD61 is known to participate in cell adhesion as well as cell-surface mediated signaling
  • Diseases associated with CD61 dysfunction include Glanzmann Thrombasthenia and Platelet type-16 Bleeding Disorder.

Compare Similar Items

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Img

Invitrogen

14-061-937

--

Antigen:
CD61 (Integrin beta 3)
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P05106
Gene Symbols:
ITGB3
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
102117791, 3690, 403788, 717379
Content And Storage:
4° C
Form:
Liquid
Applications:
Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Western Blot
Clone:
VI-PL2
Conjugate:
Unconjugated
Gene:
ITGB3
Gene Alias:
antigen CD61; BDPLT16; BDPLT2; beta3 integrin; CD61; EGK_08849; glycoprotein GPIIIa; glycoprotein IIIa; GP3A; GPIIIa; GT; INGRB3; integrin beta 3; integrin beta 3 (Cd61); integrin beta-3; integrin beta-3 subunit; integrin subunit beta 3; integrin, beta 3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); ITGB3; platelet glycoprotein IIIa; platelet glycoprotein IIIa integrin subunit beta 3; platelet gpIIIa; platelet membrane glycoprotein IIIa
Host Species:
Mouse
Quantity:
2 mg
Primary or Secondary:
Primary
Target Species:
Baboon, Canine, Cynomolgus Monkey, Human, Rhesus Monkey
Product Type:
Antibody
Isotype:
IgG1 κ

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Fischer Scientific

14-062-737

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Antigen:
CD62E (E-selectin)
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P16581, Q00690
Gene Symbols:
SELE
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
20339, 6401
Content And Storage:
4° C
Form:
Liquid
Applications:
Flow Cytometry, Functional Assay, Immunohistochemistry, Immunoprecipitation, Western Blot
Clone:
P2H3
Conjugate:
Unconjugated
Gene:
SELE
Gene Alias:
CD62 antigen-like family member E; CD62E; e selectin; Elam; ELAM1; ELAM-1; endothelial adhesion molecule 1; endothelial leukocyte adhesion molecule; endothelial leukocyte adhesion molecule 1; endothelial leukocyte adhesion molecule I; ESEL; E-selectin; LECAM2; leukocyte endothelial cell adhesion molecule 2; leukocyte-endothelial cell adhesion molecule 2; RP1-117P20.2; SELE; selectin E; selectin E (endothelial adhesion molecule 1); selectin, endothelial cell
Host Species:
Mouse
Quantity:
2 mg
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG1

Img

Fischer Scientific

14-062-795

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Antigen:
CD62E (E-selectin)
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P16581, Q00690
Gene Symbols:
SELE
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
20339, 6401
Content And Storage:
4° C
Form:
Liquid
Applications:
Flow Cytometry, Functional Assay, Immunohistochemistry, Immunoprecipitation, Western Blot
Clone:
P2H3
Conjugate:
Unconjugated
Gene:
SELE
Gene Alias:
CD62 antigen-like family member E; CD62E; e selectin; Elam; ELAM1; ELAM-1; endothelial adhesion molecule 1; endothelial leukocyte adhesion molecule; endothelial leukocyte adhesion molecule 1; endothelial leukocyte adhesion molecule I; ESEL; E-selectin; LECAM2; leukocyte endothelial cell adhesion molecule 2; leukocyte-endothelial cell adhesion molecule 2; RP1-117P20.2; SELE; selectin E; selectin E (endothelial adhesion molecule 1); selectin, endothelial cell
Host Species:
Mouse
Quantity:
10 mg
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG1

Img

Invitrogen

14-062-837

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Antigen:
CD62P (P-Selectin)
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P16109
Gene Symbols:
SELP
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
6403
Content And Storage:
4° C
Form:
Liquid
Applications:
Flow Cytometry, Functional Assay, Immunocytochemistry, Immunohistochemistry (Frozen), Neutralization
Clone:
AK-4
Conjugate:
Unconjugated
Gene:
SELP
Gene Alias:
CD62; CD62 antigen-like family member P; CD62P; CD62P antigen; CD62P; CD62 homolog; FLJ45155; GMP140; GMP-140; GMRP; Granule membrane protein 140; granule membrane protein 140kDa; granulocyte membrane protein; Grmp; LECAM3; leukocyte-endothelial cell adhesion molecule 3; PADGEM; Platelet activation dependent granule-external membrane protein; platelet alpha-granule membrane protein; PSEL; PSELECT; P-selectin; P-selectin precursor; RP1-86F14.2; selectin P; selectin P (granule membrane protein 140kDa, antigen CD62); selectin, platelet; Selp
Host Species:
Mouse
Quantity:
2 mg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1 κ