CD205 Monoclonal Antibody (MG38), eBioscience™, Invitrogen™

Description

• The MG38 MAb reacts with human CD205, also known as DEC-205, an integral membrane protein homologous to the macrophage mannose receptor
• CD205 is an endocytic dendritic receptor that mediates efficient processing and presentation of antigens on MHC class II productions in vivo
• CD205 is highly expressed by dendritic cells (DCs) within the T cell areas of lymphoid tissues, particularly on CD8^+ DCs that are believed to play a role in cross-priming
• Expression of CD205 is detected with this antibody at high intensity on in vitro derived mature human DCs (mDC) and at intermediate intensity on immature human DCs (iDC)
• All leukocytes from peripheral blood show a degree of staining with this mAb that can be minimized by using very low concentrations of MG38
• CD205 (LY25, Lymphocyte Antigen 75) is an integral membrane glycoprotein involved in antigen uptake, trafficking and presentation that improves the induction of antigen-specific T cell immunity
• CD205 is highly expressed by CD8+ dendritic cells (DCs) and also expressed at different levels by bone marrow Gr1+ cells, Langerhans cells, (BMDC) bone marrow derived DCs and thymic epithelial cells
• CD205 acts as an endocytic receptor that directs captured antigens to the extracellular space towards a specialized antigen processing region
• Further, CD205 also prompts the reduced proliferation of B lymphocytes
• Diseases associated with CD205 dysfunction include pneumonic plague and lipid pneumonia.