14-586-137
CD365 (Tim-1) Monoclonal Antibody (RMT1-4), eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 14-586-137-Each-of-1 | In Stock | ₹ 1,17,388.32 |
14-586-137 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 1,17,388.32
GST (18%): ₹ 21,129.898
Total Price: ₹ 1,38,518.218
Antigen
CD365 (Tim-1)
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
Q5QNS5
Gene Symbols
Havcr1
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
171283
Content And Storage
4° C
Form
Liquid
Applications
Flow Cytometry
Clone
RMT1-4
Conjugate
Unconjugated
Gene
Havcr1
Gene Alias
AI503787; CD365; HAVCR; HAVCR1; HAVcr-1; Hepatitis A virus cellular receptor 1; hepatitis A virus cellular receptor 1 homolog; Kidney injury molecule 1; Kim1; KIM-1; T cell immunoglobin domain and mucin domain protein 1; t cell immunoglobulin and mucin domain-containing protein 1; T cell membrane protein 1; T-cell immunoglobulin and mucin domain containing 1; T-cell immunoglobulin and mucin domain-containing protein 1; T-cell immunoglobulin mucin family member 1; T-cell immunoglobulin mucin receptor 1; T-cell membrane protein 1; TIM; TIM1; TIM-1; TIMD1; TIMD-1
Host Species
Rat
Quantity
2 mg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2b κ
Related Products
Description
- The RMT1-4 MAb reacts with mouse CD365 (also known as TIM1 and HAVCR1) and is a member of the T cell immunoglobulin domain, mucin-like domain (TIM) gene family
- CD365 has been found on activated CD4+ T cells, mast cells, and a subset of B cells
- CD365 is involved in renal injury, tissue homeostasis, and T cell costimulation
- CD365 promotes the differentiation of Th2 cells and the production of IL-4
- CD365 can bind several ligands, including Hepatitis A virus, phosphatidylserine, TIM4, IgA, as well as itself
- CD365 and TIM4 can mediate uptake of apoptotic cells through recognition of phosphatidylserine
- CD365, as well as the other TIM family members, are associated with susceptibility to atopic and autoimmune diseases
- In humans, certain polymorphic variants of CD365 are strongly associated with protection against atopy, and this association occurs only in individuals who have had past infection with hepatitis A virus (HAV)
- CD365 also known as T-cell immunoglobulin and mucin domain 1 (Tim-1) is a type 1 surface glycoprotein that consists of extracellular N-terminal immunoglobulin V-like domain and a mucin domain, and a short cytoplasmic tail
- The endogenous ligand for CD365 is Tim-4
- In addition, CD365 is known to be a cellular receptor or co-receptor for a number of viruses including hepatitis A and C viruses, Ebola virus, Marburg virus, Dengue virus, Zika virus, West Nile virus, and Japanese encephalitis virus
- The direct binding of the viruses by CD365 occurs via phosphatildyl-serine exposed on viral envelopes
- Polymorphisms within human CD365 gene (HAVCR1) are associated with susceptibility to infection and the disease severity
- CD365 has also been implicated in the T cell co-stimulation
- CD365 is primarily expressed in epithelial cells
- It is also highly expressed in A549, 769-P and Caco-2 and cell lines
- CD365 exists also as a soluble protein generated by metalloproteinase mediated proteolytic cleavage of the surface protein.
Compare Similar Items
Show Difference
Antigen: CD365 (Tim-1)
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: Q5QNS5
Gene Symbols: Havcr1
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 171283
Content And Storage: 4° C
Form: Liquid
Applications: Flow Cytometry
Clone: RMT1-4
Conjugate: Unconjugated
Gene: Havcr1
Gene Alias: AI503787; CD365; HAVCR; HAVCR1; HAVcr-1; Hepatitis A virus cellular receptor 1; hepatitis A virus cellular receptor 1 homolog; Kidney injury molecule 1; Kim1; KIM-1; T cell immunoglobin domain and mucin domain protein 1; t cell immunoglobulin and mucin domain-containing protein 1; T cell membrane protein 1; T-cell immunoglobulin and mucin domain containing 1; T-cell immunoglobulin and mucin domain-containing protein 1; T-cell immunoglobulin mucin family member 1; T-cell immunoglobulin mucin receptor 1; T-cell membrane protein 1; TIM; TIM1; TIM-1; TIMD1; TIMD-1
Host Species: Rat
Quantity: 2 mg
Primary or Secondary: Primary
Target Species: Mouse
Product Type: Antibody
Isotype: IgG2b κ
Antigen:
CD365 (Tim-1)
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
Q5QNS5
Gene Symbols:
Havcr1
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
171283
Content And Storage:
4° C
Form:
Liquid
Applications:
Flow Cytometry
Clone:
RMT1-4
Conjugate:
Unconjugated
Gene:
Havcr1
Gene Alias:
AI503787; CD365; HAVCR; HAVCR1; HAVcr-1; Hepatitis A virus cellular receptor 1; hepatitis A virus cellular receptor 1 homolog; Kidney injury molecule 1; Kim1; KIM-1; T cell immunoglobin domain and mucin domain protein 1; t cell immunoglobulin and mucin domain-containing protein 1; T cell membrane protein 1; T-cell immunoglobulin and mucin domain containing 1; T-cell immunoglobulin and mucin domain-containing protein 1; T-cell immunoglobulin mucin family member 1; T-cell immunoglobulin mucin receptor 1; T-cell membrane protein 1; TIM; TIM1; TIM-1; TIMD1; TIMD-1
Host Species:
Rat
Quantity:
2 mg
Primary or Secondary:
Primary
Target Species:
Mouse
Product Type:
Antibody
Isotype:
IgG2b κ
Antigen: CD365 (Tim-1)
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: Q5QNS5
Gene Symbols: Havcr1
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 171283
Content And Storage: 4° C
Form: Liquid
Applications: Flow Cytometry
Clone: RMT1-4
Conjugate: Unconjugated
Gene: Havcr1
Gene Alias: AI503787; CD365; HAVCR; HAVCR1; HAVcr-1; Hepatitis A virus cellular receptor 1; hepatitis A virus cellular receptor 1 homolog; Kidney injury molecule 1; Kim1; KIM-1; T cell immunoglobin domain and mucin domain protein 1; t cell immunoglobulin and mucin domain-containing protein 1; T cell membrane protein 1; T-cell immunoglobulin and mucin domain containing 1; T-cell immunoglobulin and mucin domain-containing protein 1; T-cell immunoglobulin mucin family member 1; T-cell immunoglobulin mucin receptor 1; T-cell membrane protein 1; TIM; TIM1; TIM-1; TIMD1; TIMD-1
Host Species: Rat
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Mouse
Product Type: Antibody
Isotype: IgG2b κ
Antigen:
CD365 (Tim-1)
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
Q5QNS5
Gene Symbols:
Havcr1
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
171283
Content And Storage:
4° C
Form:
Liquid
Applications:
Flow Cytometry
Clone:
RMT1-4
Conjugate:
Unconjugated
Gene:
Havcr1
Gene Alias:
AI503787; CD365; HAVCR; HAVCR1; HAVcr-1; Hepatitis A virus cellular receptor 1; hepatitis A virus cellular receptor 1 homolog; Kidney injury molecule 1; Kim1; KIM-1; T cell immunoglobin domain and mucin domain protein 1; t cell immunoglobulin and mucin domain-containing protein 1; T cell membrane protein 1; T-cell immunoglobulin and mucin domain containing 1; T-cell immunoglobulin and mucin domain-containing protein 1; T-cell immunoglobulin mucin family member 1; T-cell immunoglobulin mucin receptor 1; T-cell membrane protein 1; TIM; TIM1; TIM-1; TIMD1; TIMD-1
Host Species:
Rat
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Mouse
Product Type:
Antibody
Isotype:
IgG2b κ
Antigen: Integrin beta 7
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: P26010, P26011
Gene Symbols: ITGB7
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 16421, 3695
Content And Storage: 4° C
Form: Liquid
Applications: Flow Cytometry, Functional Assay
Clone: FIB504
Conjugate: Unconjugated
Gene: ITGB7
Gene Alias: Gut homing receptor beta subunit; integrin beta 7; integrin beta 7 subunit; integrin beta-7; Integrin beta-P; integrin subunit beta 7; integrin, beta 7; ITGB7; Ly69; M290 IEL antigen
Host Species: Rat
Quantity: 2 mg
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG2a κ
Antigen:
Integrin beta 7
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P26010, P26011
Gene Symbols:
ITGB7
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
16421, 3695
Content And Storage:
4° C
Form:
Liquid
Applications:
Flow Cytometry, Functional Assay
Clone:
FIB504
Conjugate:
Unconjugated
Gene:
ITGB7
Gene Alias:
Gut homing receptor beta subunit; integrin beta 7; integrin beta 7 subunit; integrin beta-7; Integrin beta-P; integrin subunit beta 7; integrin, beta 7; ITGB7; Ly69; M290 IEL antigen
Host Species:
Rat
Quantity:
2 mg
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG2a κ
Antigen: CD314 (NKG2D)
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: P26718
Gene Symbols: Klrk1
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 22914
Content And Storage: 4° C
Form: Liquid
Applications: Flow Cytometry, Functional Assay, Immunohistochemistry, Immunoprecipitation, Neutralization
Clone: 5C6
Conjugate: Unconjugated
Gene: Klrk1
Gene Alias: CD314; D12S2489E; D6H12S2489E; killer cell lectin like receptor K1; Killer cell lectin-like receptor subfamily K member 1; killer cell lectin-like receptor subfamily K, member 1; KLR; Klrk1; natural killer cell group 2D; natural killer cell receptor; NK cell receptor D; NK lectin-like receptor; Nkg2d; NKG2-D; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor; NKLLR; Nkrp2; NKR-P2; NKR-P2, ortholog of human NKG2D
Host Species: Mouse
Quantity: 2 mg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG2a
Antigen:
CD314 (NKG2D)
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P26718
Gene Symbols:
Klrk1
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
22914
Content And Storage:
4° C
Form:
Liquid
Applications:
Flow Cytometry, Functional Assay, Immunohistochemistry, Immunoprecipitation, Neutralization
Clone:
5C6
Conjugate:
Unconjugated
Gene:
Klrk1
Gene Alias:
CD314; D12S2489E; D6H12S2489E; killer cell lectin like receptor K1; Killer cell lectin-like receptor subfamily K member 1; killer cell lectin-like receptor subfamily K, member 1; KLR; Klrk1; natural killer cell group 2D; natural killer cell receptor; NK cell receptor D; NK lectin-like receptor; Nkg2d; NKG2-D; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor; NKLLR; Nkrp2; NKR-P2; NKR-P2, ortholog of human NKG2D
Host Species:
Mouse
Quantity:
2 mg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG2a