Angiogenin Monoclonal Antibody (26-2F), eBioscience™, Invitrogen™

Description

• The MAb 26-2F recognizes human angiogenin
• Angiogenin is a secreted ribonuclease (RNASE)-family member and is important for the formation of new blood vessels as well as the stimulation of cell proliferation and survival
• Cellular stress signals direct angiogenin to stress granules where angiogenin functions by hydrolyzing cellular tRNA resulting in modulation of protein translation and promotion of cell survival
• Cytoplasmic angiogenin can bind to actin, forming complexes that activate protease cascades which can degrade laminin and fibronectin allowing endothelial cells to penetrate the basement membrane and migrate
• In cancer cells, growth signals direct angiogenin translocation to the nucleus where binding of DNA promotor regions stimulates rRNA transcription resulting in a downstream increase in protein synthesis driving cell growth and survival
• Angiogenin is upregulated in multiple cancers including breast, prostate, cervical, colorectal, lymphoma, and melanoma
• During development and in adulthood, angiogenin is highly expressed in the spinal cord and contributes to motor neuron survival
• Angiogenin is important for neuronal survival and is depleted in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Parkinson's disease
• This 26-2F antibody is reported to have both in vivo and in vitro neutralizing activity to angiogenin
• Angiogenin (ANG or ANG I) is important for the process of neovascularization and formation of new blood vessels
• ANG is similar to pancreatic ribonuclease A and functions as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs
• It interacts with endothelial cell-surface actin and may cause changes in the cell cytoskeleton
• ANG is thought to be involved in the development of solid tumors and its antagonists are capable of inhibiting tumor growth
• Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9)
• Angiogenin is a genetic link between ALS and PD.