14-976-282
Angiogenin Monoclonal Antibody (26-2F), eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 14-976-282-Each-of-1 | In Stock | ₹ 32,512.80 |
14-976-282 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 32,512.80
GST (18%): ₹ 5,852.304
Total Price: ₹ 38,365.104
Antigen
Angiogenin
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
P03950
Gene Symbols
ANG
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
283
Content And Storage
4° C
Form
Liquid
Applications
ELISA, Functional Assay, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Neutralization
Clone
26-2F
Conjugate
Unconjugated
Gene
ANG
Gene Alias
AI385586; ALS9; ANG; Ang1; Angiogenin; angiogenin ribonuclease 1; angiogenin, ribonuclease A family, member 1; angiogenin, ribonuclease, RNase A family, 5; angiogenin-1; epididymis luminal protein 168; HEL168; MGC22466; MGC71966; RAA1; Ribonuclease 5; ribonuclease A A1; ribonuclease A family member 5; RNase 5; RNASE4; RNASE5; Rnase5a
Host Species
Mouse
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
Related Products
Description
- The MAb 26-2F recognizes human angiogenin
- Angiogenin is a secreted ribonuclease (RNASE)-family member and is important for the formation of new blood vessels as well as the stimulation of cell proliferation and survival
- Cellular stress signals direct angiogenin to stress granules where angiogenin functions by hydrolyzing cellular tRNA resulting in modulation of protein translation and promotion of cell survival
- Cytoplasmic angiogenin can bind to actin, forming complexes that activate protease cascades which can degrade laminin and fibronectin allowing endothelial cells to penetrate the basement membrane and migrate
- In cancer cells, growth signals direct angiogenin translocation to the nucleus where binding of DNA promotor regions stimulates rRNA transcription resulting in a downstream increase in protein synthesis driving cell growth and survival
- Angiogenin is upregulated in multiple cancers including breast, prostate, cervical, colorectal, lymphoma, and melanoma
- During development and in adulthood, angiogenin is highly expressed in the spinal cord and contributes to motor neuron survival
- Angiogenin is important for neuronal survival and is depleted in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Parkinson's disease
- This 26-2F antibody is reported to have both in vivo and in vitro neutralizing activity to angiogenin
- Angiogenin (ANG or ANG I) is important for the process of neovascularization and formation of new blood vessels
- ANG is similar to pancreatic ribonuclease A and functions as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs
- It interacts with endothelial cell-surface actin and may cause changes in the cell cytoskeleton
- ANG is thought to be involved in the development of solid tumors and its antagonists are capable of inhibiting tumor growth
- Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9)
- Angiogenin is a genetic link between ALS and PD.
Compare Similar Items
Show Difference
Antigen: Angiogenin
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: P03950
Gene Symbols: ANG
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 283
Content And Storage: 4° C
Form: Liquid
Applications: ELISA, Functional Assay, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Neutralization
Clone: 26-2F
Conjugate: Unconjugated
Gene: ANG
Gene Alias: AI385586; ALS9; ANG; Ang1; Angiogenin; angiogenin ribonuclease 1; angiogenin, ribonuclease A family, member 1; angiogenin, ribonuclease, RNase A family, 5; angiogenin-1; epididymis luminal protein 168; HEL168; MGC22466; MGC71966; RAA1; Ribonuclease 5; ribonuclease A A1; ribonuclease A family member 5; RNase 5; RNASE4; RNASE5; Rnase5a
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1 κ
Antigen:
Angiogenin
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P03950
Gene Symbols:
ANG
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
283
Content And Storage:
4° C
Form:
Liquid
Applications:
ELISA, Functional Assay, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Neutralization
Clone:
26-2F
Conjugate:
Unconjugated
Gene:
ANG
Gene Alias:
AI385586; ALS9; ANG; Ang1; Angiogenin; angiogenin ribonuclease 1; angiogenin, ribonuclease A family, member 1; angiogenin, ribonuclease, RNase A family, 5; angiogenin-1; epididymis luminal protein 168; HEL168; MGC22466; MGC71966; RAA1; Ribonuclease 5; ribonuclease A A1; ribonuclease A family member 5; RNase 5; RNASE4; RNASE5; Rnase5a
Host Species:
Mouse
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1 κ
Antigen: Progesterone Receptor
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: P06401
Gene Symbols: PGR
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 5241
Content And Storage: 4° C
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin)
Clone: KMC912
Conjugate: Unconjugated
Gene: PGR
Gene Alias: 9930019P03Rik; BB114106; ENSMUSG00000074510; LOW QUALITY PROTEIN: progesterone receptor; NR3C3; Nuclear receptor subfamily 3 group C member 3; p4 receptor; PGR; pot. alt. progesterone receptor; putative; PR; PR-A; PR-B; Progesterone receptor; progesterone receptor A; progesterone-receptor; putative form B; steroid hormone receptor; testicular progesterone receptor; unnamed protein product
Host Species: Mouse
Quantity: 2 mg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1 κ
Antigen:
Progesterone Receptor
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P06401
Gene Symbols:
PGR
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
5241
Content And Storage:
4° C
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin)
Clone:
KMC912
Conjugate:
Unconjugated
Gene:
PGR
Gene Alias:
9930019P03Rik; BB114106; ENSMUSG00000074510; LOW QUALITY PROTEIN: progesterone receptor; NR3C3; Nuclear receptor subfamily 3 group C member 3; p4 receptor; PGR; pot. alt. progesterone receptor; putative; PR; PR-A; PR-B; Progesterone receptor; progesterone receptor A; progesterone-receptor; putative form B; steroid hormone receptor; testicular progesterone receptor; unnamed protein product
Host Species:
Mouse
Quantity:
2 mg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1 κ
Antigen: Progesterone Receptor
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: P06401
Gene Symbols: PGR
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 5241
Content And Storage: 4° C
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin)
Clone: KMC912
Conjugate: Unconjugated
Gene: PGR
Gene Alias: 9930019P03Rik; BB114106; ENSMUSG00000074510; LOW QUALITY PROTEIN: progesterone receptor; NR3C3; Nuclear receptor subfamily 3 group C member 3; p4 receptor; PGR; pot. alt. progesterone receptor; putative; PR; PR-A; PR-B; Progesterone receptor; progesterone receptor A; progesterone-receptor; putative form B; steroid hormone receptor; testicular progesterone receptor; unnamed protein product
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1 κ
Antigen:
Progesterone Receptor
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P06401
Gene Symbols:
PGR
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
5241
Content And Storage:
4° C
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin)
Clone:
KMC912
Conjugate:
Unconjugated
Gene:
PGR
Gene Alias:
9930019P03Rik; BB114106; ENSMUSG00000074510; LOW QUALITY PROTEIN: progesterone receptor; NR3C3; Nuclear receptor subfamily 3 group C member 3; p4 receptor; PGR; pot. alt. progesterone receptor; putative; PR; PR-A; PR-B; Progesterone receptor; progesterone receptor A; progesterone-receptor; putative form B; steroid hormone receptor; testicular progesterone receptor; unnamed protein product
Host Species:
Mouse
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1 κ
Antigen: CD4
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: P06332
Gene Symbols: CD4
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 12504
Content And Storage: 4° C
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: 4SM95
Conjugate: Unconjugated
Gene: CD4
Gene Alias: Activation B7-1 antigen; B7; B7.1; B7-1; BB1; B-lymphocyte activation antigen B7; CD28LG; CD28LG1; CD4; CD4 antigen; CD4 antigen (p55); CD4 antigen p55; Cd4 molecule; CD4 precursor; CD4 receptor; CD4, allele 1; cd4a; CD4mut; CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); CD80 molecule; cell surface glycoprotein CD4; costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; fCD4; L3T4; LAB7; Leu-3; Ly-4; lymphocyte antigen CD4; lymphocyte antigen CD4 precursor; membrane protein; p55; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4); T-lymphocyte activation antigen CD80; W3/25; W3/25 antigen
Host Species: Rat
Quantity: 2 mg
Primary or Secondary: Primary
Target Species: Mouse
Product Type: Antibody
Isotype: IgG1 κ
Antigen:
CD4
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P06332
Gene Symbols:
CD4
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
12504
Content And Storage:
4° C
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
4SM95
Conjugate:
Unconjugated
Gene:
CD4
Gene Alias:
Activation B7-1 antigen; B7; B7.1; B7-1; BB1; B-lymphocyte activation antigen B7; CD28LG; CD28LG1; CD4; CD4 antigen; CD4 antigen (p55); CD4 antigen p55; Cd4 molecule; CD4 precursor; CD4 receptor; CD4, allele 1; cd4a; CD4mut; CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); CD80 molecule; cell surface glycoprotein CD4; costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; fCD4; L3T4; LAB7; Leu-3; Ly-4; lymphocyte antigen CD4; lymphocyte antigen CD4 precursor; membrane protein; p55; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4); T-lymphocyte activation antigen CD80; W3/25; W3/25 antigen
Host Species:
Rat
Quantity:
2 mg
Primary or Secondary:
Primary
Target Species:
Mouse
Product Type:
Antibody
Isotype:
IgG1 κ