Dynein Monoclonal Antibody (74.1), eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 14-977-280-Each-of-1 | In Stock | ₹ 12,727.00 |
14-977-280 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 12,727.00
GST (18%): ₹ 2,290.86
Total Price: ₹ 15,017.86
Antigen
Dynein
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% Sodium Azide; pH 7.2
Gene Accession No.
P61285, P63167, P63168, P63170, Q3MHR3, Q78P75, Q96FJ2, Q9D0M5
Gene Symbols
DYNLL1, DYNLL2
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
100157773, 100512860, 101118902, 101121274, 140734, 140735, 404151, 540369, 56455, 58945, 68097, 8655
Content And Storage
4° C
Form
Liquid
Applications
ELISA, Flow Cytometry, Immunocytochemistry, Immunoprecipitation, Western Blot
Clone
74.1
Conjugate
Unconjugated
Gene
DYNLL1
Gene Alias
1700064A15Rik; 6720463E02Rik; 8 kDa dynein light chain; 8 kDa dynein light chain b; 8kD LC; 8kDa LC; 8kDLC; C87222; CDLC2; cytoplasmic dynein light polypeptide; cytoplasmic dynein light polypeptide 1; cytoplasmic light-chain dynein; cytosolic DH IC-1; DLC1; Dlc2; DLC8; DLC8b; DNCL1; DNCL1B; Dnclc1; dynein LC8; dynein light chain 1, cytoplasmic; Dynein light chain 2, cytoplasmic; dynein light chain LC8-type 1; Dynein light chain LC8-type 2; dynein light chain-2; dynein, cytoplasmic, light chain 1; dynein, cytoplasmic, light peptide; dynein, cytoplasmic, light polypeptide 1; dynein, light chain, LC8-type 1; dynein, light chain, LC8-type 2; DYNLL1; DYNLL2; HDLC1; LC8; LC8; PIN; LC8a; LOC540369 protein; mPIN; PIN; Protein inhibitor of neuronal nitric oxide synthase; protein inhibitor of nitric oxide synthase; radial spoke 22 homolog; RSPH22; similar to cytoplasmic dynein light chain 1
Host Species
Mouse
Quantity
25 μg
Primary or Secondary
Primary
Target Species
Bovine, Drosophila, Human, Mouse, Ovine, Porcine, Rat, X. laevis
Product Type
Antibody
Isotype
IgG2b κ
Related Products
Description
- The monoclonal antibody 74.1 recognizes all known forms of the 74 kDa intermediate chain subunit of mammalian cytoplasmic dynein
- Cytoplasmic dynein is a microtubule-stimulated ATPase responsible for movement of membrane-bound organelles in a directed manner toward the minus end of microtubules, commonly found at the centrosome
- Dynein is responsible for the transport of lysosomes, endosomes, phagosomes, peroxisomes, mitochondria, and vesicles from the endoplasmic reticulum destined for the Golgi
- During mitosis, dynein is responsible for positioning the spindle apparatus as well as being localized to the kinetochores to facilitate chromosome movement.The 74.1 antibody recognizes human, mouse, rat, bovine, sheep, Xenopus, porcine, and Drosophila dynein intermediate chain
- This 74.1 antibody has been tested by immunocytochemistry of methanol-fixed and permeabilized cells and can be used at less than or equal to 1 μg/mL
- This 74.1 antibody has been tested by western blot of reduced and non-reduced HeLa cell lysate and can be used at less than or equal to 5 μg/mL
- It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
- Purity: Greater than 90%, as determined by SDS-PAGE
- Aggregation: Less than 10%, as determined by HPLC
- Filtration: 0.2 μm post-manufacturing filtered
- The directed movement of membrane-bounded organelles is an important process for various cellular functions including membrane transport, secretion, and axonal transport
- Cytoplasmic dynein, a ubiquitous minus end-directed microtubule-based motor protein, is believed to be responsible for the retrograde transport of membranous organelles from the synapse to the cell body in fast axonal transport
- The cytoplasmic dynein complex is composed of two ∽530 kDa heavy chains, and intermediate chains of ∽74 kDa and ∽53-59 kDa.