14-977-637
ZO-1 Monoclonal Antibody (R26.4C), eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 14-977-637-Each-of-1 | In Stock | ₹ 1,17,901.68 |
14-977-637 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 1,17,901.68
GST (18%): ₹ 21,222.302
Total Price: ₹ 1,39,123.982
Antigen
ZO-1
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
O97758, P39447
Gene Symbols
TJP1
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
21872, 292994, 403752
Content And Storage
4° C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Frozen), Western Blot
Clone
R26.4C
Conjugate
Unconjugated
Gene
TJP1
Gene Alias
DKFZp686M05161; I79_005485; MGC133289; OTTHUMP00000174520; Tight junction protein 1; tight junction protein 1 (zona occludens 1); tight junction protein ZO-1; Tjp1; zo1; ZO-1; ZO-1 MDCK; zona occludens 1; zona occludens protein 1; zonula occludens 1; zonula occludens 1 protein; zonula occludens protein 1
Host Species
Rat
Quantity
2 mg
Primary or Secondary
Primary
Target Species
Canine, Mouse, Rat
Product Type
Antibody
Isotype
IgG2a κ
Related Products
Description
- Description The MAb R26.4C recognizes the tight junction protein 1, ZO-1 (zona occludens) of rat, mouse, canine, and porcine
- ZO-1 is a member of the MAGUK family of tight junction associated scaffolding proteins, each containing a PDZ, SH3 and guanylate kinase-like (GUK) domain
- ZO-1 is an integral member of the tight junction complex which forms a barrier to paracellular movement of substances, separating apical and basolateral fluids in relation to the epithelial cell layer
- ZO-1 forms complexes with family members ZO-2, ZO-3, as well as occludin, cingulin, claudin-1-8, actin, alpha-catenin, the Ras-effector molecule AF-6, ZONAB, Apg-2, and the junctional adhesion molecules (JAM)-A-C
- ZO-1 is thought to anchor the actin cytoskeleton to the tight junction
- ZO-1 and ZO-2 have been shown to regulate cell cycle and proliferation with recent evidence highlighting the down-regulation of ZO-1 and ZO-2 with cancer progression
- ZO-1 forms complexes with either ZO-2 or ZO-3
- In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction
- ZO-1 expression is significantly reduced in many breast cancer lines
- ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue
- ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions
- ZO-1 may be involved in signal transduction at cell-cell junctions
- Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene
- Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.
Compare Similar Items
Show Difference
Antigen: ZO-1
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: O97758, P39447
Gene Symbols: TJP1
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 21872, 292994, 403752
Content And Storage: 4° C
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Frozen), Western Blot
Clone: R26.4C
Conjugate: Unconjugated
Gene: TJP1
Gene Alias: DKFZp686M05161; I79_005485; MGC133289; OTTHUMP00000174520; Tight junction protein 1; tight junction protein 1 (zona occludens 1); tight junction protein ZO-1; Tjp1; zo1; ZO-1; ZO-1 MDCK; zona occludens 1; zona occludens protein 1; zonula occludens 1; zonula occludens 1 protein; zonula occludens protein 1
Host Species: Rat
Quantity: 2 mg
Primary or Secondary: Primary
Target Species: Canine, Mouse, Rat
Product Type: Antibody
Isotype: IgG2a κ
Antigen:
ZO-1
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
O97758, P39447
Gene Symbols:
TJP1
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
21872, 292994, 403752
Content And Storage:
4° C
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Frozen), Western Blot
Clone:
R26.4C
Conjugate:
Unconjugated
Gene:
TJP1
Gene Alias:
DKFZp686M05161; I79_005485; MGC133289; OTTHUMP00000174520; Tight junction protein 1; tight junction protein 1 (zona occludens 1); tight junction protein ZO-1; Tjp1; zo1; ZO-1; ZO-1 MDCK; zona occludens 1; zona occludens protein 1; zonula occludens 1; zonula occludens 1 protein; zonula occludens protein 1
Host Species:
Rat
Quantity:
2 mg
Primary or Secondary:
Primary
Target Species:
Canine, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG2a κ
Antigen: LAMP5 (BAD-LAMP)
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% Sodium Azide; pH 7.2
Gene Accession No.: Q9UJQ1
Gene Symbols: LAMP5
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 24141
Content And Storage: 4° C
Form: Liquid
Applications: ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: 34.2
Conjugate: Unconjugated
Gene: LAMP5
Gene Alias: 3110035N03Rik; 6330527O06Rik; BADLAMP; BAD-LAMP; brain and dendritic cell associated LAMP; brain and dendritic cell-associated LAMP; Brain-associated LAMP-like protein; C20orf103; LAMP family protein C20orf103; LAMP family protein C20orf103 homolog; LAMP5; LAMP-5; lysosomal associated membrane protein family member 5; lysosomal-associated membrane protein family, member 5; lysosome-associated membrane glycoprotein 5; Lysosome-associated membrane protein 5; Protein C20orf103; RGD1306991; UNC-46
Host Species: Rat
Quantity: 2 mg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1 κ
Antigen:
LAMP5 (BAD-LAMP)
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% Sodium Azide; pH 7.2
Gene Accession No.:
Q9UJQ1
Gene Symbols:
LAMP5
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
24141
Content And Storage:
4° C
Form:
Liquid
Applications:
ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
34.2
Conjugate:
Unconjugated
Gene:
LAMP5
Gene Alias:
3110035N03Rik; 6330527O06Rik; BADLAMP; BAD-LAMP; brain and dendritic cell associated LAMP; brain and dendritic cell-associated LAMP; Brain-associated LAMP-like protein; C20orf103; LAMP family protein C20orf103; LAMP family protein C20orf103 homolog; LAMP5; LAMP-5; lysosomal associated membrane protein family member 5; lysosomal-associated membrane protein family, member 5; lysosome-associated membrane glycoprotein 5; Lysosome-associated membrane protein 5; Protein C20orf103; RGD1306991; UNC-46
Host Species:
Rat
Quantity:
2 mg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1 κ
Antigen: Arginase 1
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: P05089
Gene Symbols: ARG1
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 383
Content And Storage: 4° C
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone: sl6arg
Conjugate: Unconjugated
Gene: ARG1
Gene Alias: AI; A-I; AI type I arginase; AI256583; Arg1; Arg-1; Arginase; arginase 1; arginase 1 liver; arginase 1, liver; arginase I; arginase, liver; Arginase1; arginase-1; HGNC:663; Liver Arginase; Liver-type arginase; PGIF; similar to arginase, type I; Type 1 Arginase; type I arginase
Host Species: Mouse
Quantity: 2 mg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1 κ
Antigen:
Arginase 1
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P05089
Gene Symbols:
ARG1
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
383
Content And Storage:
4° C
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone:
sl6arg
Conjugate:
Unconjugated
Gene:
ARG1
Gene Alias:
AI; A-I; AI type I arginase; AI256583; Arg1; Arg-1; Arginase; arginase 1; arginase 1 liver; arginase 1, liver; arginase I; arginase, liver; Arginase1; arginase-1; HGNC:663; Liver Arginase; Liver-type arginase; PGIF; similar to arginase, type I; Type 1 Arginase; type I arginase
Host Species:
Mouse
Quantity:
2 mg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1 κ
Antigen: Cytokeratin 6
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: P02538, P04259, P48668
Gene Symbols: KRT6A, KRT6B, KRT6C
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 286887, 3853, 3854
Content And Storage: 4° C
Form: Liquid
Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
Clone: LL020
Conjugate: Unconjugated
Gene: KRT6C
Gene Alias: 2310016L08Rik; 60-kDa keratin; BB144589; CK6A; CK-6A; CK6B; CK-6B; CK6C; CK-6C; CK6D; CK-6D; CK-6E; cytokeratin 6A; cytokeratin 6B; cytokeratin 6C; cytokeratin 6D; cytokeratin-6A; Cytokeratin-6B; cytokeratin-6C; Cytokeratin-6D; Cytokeratin-6E; Hom s 5; K6A; K6a keratin; K6B; K6C; K6D; K6E; kamp-keratin derived antimicrobial peptide; KDAMP; Ker2; keratin 6A; keratin 6A, , type II; keratin 6A, type II; keratin 6B; keratin 6B, type II; keratin 6C; keratin 6C, type II; keratin 6E; keratin complex 2, basic, gene 6a; keratin complex 2, basic, gene 6b; keratin complex 2, basic, gene 6c; keratin complex 2, gene 6a; keratin K6; keratin K6h; keratin, epidermal type II, K6A; keratin, epidermal, type II, K6B; keratin, type II cytoskeletal 6A; Keratin, type II cytoskeletal 6B; keratin, type II cytoskeletal 6C; keratin-6A; Keratin-6-alpha; Keratin-6B; keratin-6-beta; keratin-6C; keratin-like 1 (a type II keratin sequence); Krt2-6; Krt2-6a; Krt2-6b; Krt2-6c; Krt6; Krt6a; Krt6b; KRT6C; KRT6D; KRT6E; KRTL1; LOC683313; mK6[a]; mK6[b]; MK6a; mK6-alpha; mK6-beta; PC2; PC3; PC4; PPKNEFD; similar to keratin complex 2, basic, gene 6a; type-II keratin Kb10; Type-II keratin Kb12; type-II keratin Kb6
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgM κ
Antigen:
Cytokeratin 6
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P02538, P04259, P48668
Gene Symbols:
KRT6A, KRT6B, KRT6C
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
286887, 3853, 3854
Content And Storage:
4° C
Form:
Liquid
Applications:
ELISA, Immunohistochemistry (Paraffin), Western Blot
Clone:
LL020
Conjugate:
Unconjugated
Gene:
KRT6C
Gene Alias:
2310016L08Rik; 60-kDa keratin; BB144589; CK6A; CK-6A; CK6B; CK-6B; CK6C; CK-6C; CK6D; CK-6D; CK-6E; cytokeratin 6A; cytokeratin 6B; cytokeratin 6C; cytokeratin 6D; cytokeratin-6A; Cytokeratin-6B; cytokeratin-6C; Cytokeratin-6D; Cytokeratin-6E; Hom s 5; K6A; K6a keratin; K6B; K6C; K6D; K6E; kamp-keratin derived antimicrobial peptide; KDAMP; Ker2; keratin 6A; keratin 6A, , type II; keratin 6A, type II; keratin 6B; keratin 6B, type II; keratin 6C; keratin 6C, type II; keratin 6E; keratin complex 2, basic, gene 6a; keratin complex 2, basic, gene 6b; keratin complex 2, basic, gene 6c; keratin complex 2, gene 6a; keratin K6; keratin K6h; keratin, epidermal type II, K6A; keratin, epidermal, type II, K6B; keratin, type II cytoskeletal 6A; Keratin, type II cytoskeletal 6B; keratin, type II cytoskeletal 6C; keratin-6A; Keratin-6-alpha; Keratin-6B; keratin-6-beta; keratin-6C; keratin-like 1 (a type II keratin sequence); Krt2-6; Krt2-6a; Krt2-6b; Krt2-6c; Krt6; Krt6a; Krt6b; KRT6C; KRT6D; KRT6E; KRTL1; LOC683313; mK6[a]; mK6[b]; MK6a; mK6-alpha; mK6-beta; PC2; PC3; PC4; PPKNEFD; similar to keratin complex 2, basic, gene 6a; type-II keratin Kb10; Type-II keratin Kb12; type-II keratin Kb6
Host Species:
Mouse
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgM κ