50-113-0711
ZO-1 Monoclonal Antibody (R26.4C), eFluor™ 570, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each | 50-113-0711-Each | In Stock | ₹ 39,395.85 |
50-113-0711 - Each
In Stock
Quantity
1
Base Price: ₹ 39,395.85
GST (18%): ₹ 7,091.253
Total Price: ₹ 46,487.103
Antigen
ZO-1
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
O97758, P39447
Gene Symbols
TJP1
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
21872, 292994, 403752
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Frozen)
Clone
R26.4C
Conjugate
eFluor 570
Gene
TJP1
Gene Alias
DKFZp686M05161; I79_005485; MGC133289; OTTHUMP00000174520; Tight junction protein 1; tight junction protein 1 (zona occludens 1); tight junction protein ZO-1; Tjp1; zo1; ZO-1; ZO-1 MDCK; zona occludens 1; zona occludens protein 1; zonula occludens 1; zonula occludens 1 protein; zonula occludens protein 1
Host Species
Rat
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Canine, Mouse, Rat
Product Type
Antibody
Isotype
IgG2a κ
Related Products
Description
- Description: The monoclonal antibody R26.4C recognizes the tight junction protein 1, ZO-1 (zona occludens) of rat, mouse, canine, and porcine
- ZO-1 is a member of the MAGUK family of tight junction associated scaffolding proteins, each containing a PDZ, SH3 and guanylate kinase-like (GUK) domain
- ZO-1 is an integral member of the tight junction complex which forms a barrier to paracellular movement of substances, separating apical and basolateral fluids in relation to the epithelial cell layer
- ZO-1 forms complexes with family members ZO-2, ZO-3, as well as occludin, cingulin, claudin-1-8, actin, alpha-catenin, the Ras-effector molecule AF-6, ZONAB, Apg-2, and the junctional adhesion molecules (JAM)-A-C
- ZO-1 is thought to anchor the actin cytoskeleton to the tight junction
- ZO-1 and ZO-2 have been shown to regulate cell cycle and proliferation with recent evidence highlighting the down-regulation of ZO-1 and ZO-2 with cancer progression
- Applications Reported: This R26.4C antibody has been reported for use in immunohistochemical staining of frozen tissue sections, microscopy, and immunocytochemistry
- Applications Tested: This R26.4C antibody has been tested by immunocytochemistry of formaldehyde-fixed and permeablized cells and can be used at less than or equal to 1 μg/mL
- It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
- ZO-1 forms complexes with either ZO-2 or ZO-3
- In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction
- ZO-1 expression is significantly reduced in many breast cancer lines
- ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue
- ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions
- ZO-1 may be involved in signal transduction at cell-cell junctions
- Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene
- Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.
Compare Similar Items
Show Difference
Antigen: ZO-1
Classification: Monoclonal
Concentration: 0.2 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: O97758, P39447
Gene Symbols: TJP1
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 21872, 292994, 403752
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Frozen)
Clone: R26.4C
Conjugate: eFluor 570
Gene: TJP1
Gene Alias: DKFZp686M05161; I79_005485; MGC133289; OTTHUMP00000174520; Tight junction protein 1; tight junction protein 1 (zona occludens 1); tight junction protein ZO-1; Tjp1; zo1; ZO-1; ZO-1 MDCK; zona occludens 1; zona occludens protein 1; zonula occludens 1; zonula occludens 1 protein; zonula occludens protein 1
Host Species: Rat
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Canine, Mouse, Rat
Product Type: Antibody
Isotype: IgG2a κ
Antigen:
ZO-1
Classification:
Monoclonal
Concentration:
0.2 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
O97758, P39447
Gene Symbols:
TJP1
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
21872, 292994, 403752
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Frozen)
Clone:
R26.4C
Conjugate:
eFluor 570
Gene:
TJP1
Gene Alias:
DKFZp686M05161; I79_005485; MGC133289; OTTHUMP00000174520; Tight junction protein 1; tight junction protein 1 (zona occludens 1); tight junction protein ZO-1; Tjp1; zo1; ZO-1; ZO-1 MDCK; zona occludens 1; zona occludens protein 1; zonula occludens 1; zonula occludens 1 protein; zonula occludens protein 1
Host Species:
Rat
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Canine, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG2a κ
Antigen: SOX2
Classification: Monoclonal
Concentration: 0.2 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: P48431, P48432
Gene Symbols: SOX2
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 20674, 6657
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry
Clone: Btjce
Conjugate: eFluor 570
Gene: SOX2
Gene Alias: ANOP3; cb236; Delta EF2a; lcc; MCOPS3; MCOPS3 (Microphthalmia Syndromic type 3); RGD1565646; sex determining region Y-box 2; SOX 2; SOX2; Sox-2; soxp; SRY (sex determining region Y) box 2; SRY (sex determining region Y)-box 2; SRY box 2; SRY related HMG box 2; SRY-box 2; SRY-box 2; SOX2; SRY-box containing gene 2; SRY-box transcription factor 2; SRY-related HMG-box gene 2; transcription factor SOX2; transcription factor SOX-2; wu:fb83g04; wu:fc14d07; ysb; zgc:65860; zgc:77389
Host Species: Rat
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG2a κ
Antigen:
SOX2
Classification:
Monoclonal
Concentration:
0.2 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P48431, P48432
Gene Symbols:
SOX2
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
20674, 6657
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry
Clone:
Btjce
Conjugate:
eFluor 570
Gene:
SOX2
Gene Alias:
ANOP3; cb236; Delta EF2a; lcc; MCOPS3; MCOPS3 (Microphthalmia Syndromic type 3); RGD1565646; sex determining region Y-box 2; SOX 2; SOX2; Sox-2; soxp; SRY (sex determining region Y) box 2; SRY (sex determining region Y)-box 2; SRY box 2; SRY related HMG box 2; SRY-box 2; SRY-box 2; SOX2; SRY-box containing gene 2; SRY-box transcription factor 2; SRY-related HMG-box gene 2; transcription factor SOX2; transcription factor SOX-2; wu:fb83g04; wu:fc14d07; ysb; zgc:65860; zgc:77389
Host Species:
Rat
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG2a κ
Antigen: Phospho-Histone H2A.X (Ser139)
Classification: Monoclonal
Concentration: 0.2 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: P16104, P27661
Gene Symbols: H2AX
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 15270, 3014
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone: CR55T33
Conjugate: eFluor 570
Gene: H2AX
Gene Alias: AW228881; gamma H2AX; gammaH2ax; H2A histone family member X; H2A histone family, member X; H2A.X; H2A.X variant histone; H2A/X; h2afx; H2ax; H2AX histone; Hist5-2ax; histone 5 protein 2ax; histone H2A.x; Histone H2a/x; Histone H2AX; RGD1566119; similar to H2A histone family, member X; zgc:56329
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG1 κ
Antigen:
Phospho-Histone H2A.X (Ser139)
Classification:
Monoclonal
Concentration:
0.2 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P16104, P27661
Gene Symbols:
H2AX
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
15270, 3014
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone:
CR55T33
Conjugate:
eFluor 570
Gene:
H2AX
Gene Alias:
AW228881; gamma H2AX; gammaH2ax; H2A histone family member X; H2A histone family, member X; H2A.X; H2A.X variant histone; H2A/X; h2afx; H2ax; H2AX histone; Hist5-2ax; histone 5 protein 2ax; histone H2A.x; Histone H2a/x; Histone H2AX; RGD1566119; similar to H2A histone family, member X; zgc:56329
Host Species:
Mouse
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG1 κ
Antigen: __
Classification: __
Concentration: 0.2 mg/mL
Formulation: __
Gene Accession No.: __
Gene Symbols: __
Purification Method: __
Regulatory Status: __
Gene ID (Entrez): __
Content And Storage: __
Form: Liquid
Applications: __
Clone: __
Conjugate: eFluor 615
Gene: __
Gene Alias: __
Host Species: __
Quantity: 100 μg
Primary or Secondary: __
Target Species: __
Product Type: Streptavidin Conjugate (fluorescent)
Isotype: __
Antigen:
__
Classification:
__
Concentration:
0.2 mg/mL
Formulation:
__
Gene Accession No.:
__
Gene Symbols:
__
Purification Method:
__
Regulatory Status:
__
Gene ID (Entrez):
__
Content And Storage:
__
Form:
Liquid
Applications:
__
Clone:
__
Conjugate:
eFluor 615
Gene:
__
Gene Alias:
__
Host Species:
__
Quantity:
100 μg
Primary or Secondary:
__
Target Species:
__
Product Type:
Streptavidin Conjugate (fluorescent)
Isotype:
__