IL-15 Monoclonal Antibody (AIO.3), Functional Grade, eBioscience™, Invitrogen™

Description

• The AIO.3 antibody reacts with mouse IL-15
• This is a neutralizing antibody
• Mouse IL-15 is a 14-15 kDa factor, previously known as IL-T
• IL-15 is produced by a variety of cells and has a role in the T cell-mediated immune response and the central nervous system
• IL-15 binds to the beta and gamma subunits of the IL-2 receptor; however, these two cytokines have distinct biological activities
• IL-15 is a specific maturation factor for NK cells and mimics the BM microenvironment for NK cell development in vitro
• It is reported that IL-15 delivers an anti-apoptotic and survival signal for NK, T, and B cells
• IL-15 (Interleukin 15 ) is a cytokine that regulates T and natural killer cell activation and proliferation
• IL-15 and IL-2 share many biological activities as both have been found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity
• The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2
• IL-15 induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6
• In mouse, studies suggest that IL-15 may increase the expression of apoptosis inhibitor Bcl-xL, possibly through the transcription activation activity of STAT6, and thus prevent apoptosis
• IL-15 plays an important role in the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monocytes as well as activation of a number of important intracellular signaling molecules
• As such, IL-15 could be essential for the immune responses, allograft rejection, and the pathogenesis of autoimmune diseases
• Further, IL-15 is a widely expressed pro-inflammatory cytokine and has been shown to play a role in several inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary inflammatory diseases
• Emerging data suggest that IL-15 may serve as a good therapeutic target, as there appears to be a beneficial effect of IL-15 neutralization in models of psoriasis and diabetes.