CD266 (TWEAK Receptor) Monoclonal Antibody (ITEM-4), Functional Grade, eBioscience™, Invitrogen™

Description

• Description The ITEM-4 antibody reacts with human TWEAK Receptor/Fn14 (fibroblast growth factor-inducible 14 kDa protein)
• Fn14 is distantly related to the TNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain (DD) cytoplasmic region
• Fn14 plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis
• TWEAK-induced cell death via Fn14 includes both apoptosis and necrosis and can be blocked by an anti-TWEAK antibody, CARL-1
• Fn14 is expressed on HUVEC and in some cancer tissues but not on freshly isolated PBMCs
• Fn14 mRNA expression has been identified during liver regeneration
• It has been reported that ITEM-4 cross-reacts with mouse Fn14
• In the mouse, Fn14 is reported to be constitutively expressed by Colon 26 cell line
• The ITEM-4 antibody has been show to have blocking function
• TWEAK is a member of the TNF family and was first described as a weak inducer of apoptosis in demonstrate that this relatively small molecule is a fully transformed cell lines
• Recently, a receptor for TWEAK was isolated by expression cloning from a HUVEC cell cDNA library
• TweakR is a small protein belonging to TNF receptor super family
• TweakR is capable of intiating a proliferative signal by binding to TRAF1, 2, and 3
• TweakR mRNA is upregulated during tissue regeneration in the aorta and liver
• It may also play a role in vascular cell migration and angiogenesis.