CD8a Monoclonal Antibody (53-6.7), Brilliant Violet™ 605, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD8a
Concentration
0.2 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with BSA and 0.09% sodium azide, pH 7.2
Gene Alias
BB154331, CD8, CD8 alpha, CD8 alpha chain, CD8 alpha chain precursor, CD8 antigen, CD8 antigen 32 kDa chain, CD8 antigen 37 kDa chain, CD8 antigen alpha polypeptide, CD8 antigen alpha protein, CD8 antigen alpha protein precursor, CD8 antigen alpha-chain, CD8 antigen beta polypeptide, CD8 antigen beta polypeptide precursor, CD8 antigen beta-chain, CD8 antigen, alpha chain, CD8 antigen, alpha polypeptide, CD8 antigen, alpha polypeptide (p32), CD8 antigen, alpha-chain, CD8 antigen, beta chain, CD8 antigen, beta chain 1, CD8 antigen, beta polypeptide, CD8 antigen, beta polypeptide 1 (p37), CD8 antigen, beta-chain, CD8 beta, CD8 beta chain, CD8 beta-2, CD8a, CD8A antigen alpha, CD8a molecule, CD8A, T-cell surface glycoprotein, CD8alpha, CD8B, CD8b antigen, CD8b molecule, CD8b molecule pseudogene, Cd8b1, CD8beta, CD8BP, fCD8, LEU2, Leu-2, Leu2 T-lymphocyte antigen, leu-2a, Ly-2, LY3, Ly-3, Ly-35, Ly-B, Ly-C, Lymphocyte antigen 3, Lyt2, Lyt-2, Lyt-2.1 lymphocyte differentiation antigen (AA at 100), Lyt3, Lyt-3, MAL, membrane glycoprotein, membrane protein, OKT8 T-cell antigen, OX-8 membrane antigen, p32, P37, RHACD8-4, T cell co-receptor, T lymphocyte surface glycoprotein beta chain, T8 T-cell antigen, T-cell antigen Leu2, T-cell membrane glycoprotein Ly-3, T-cell surface glycoprotein, T-cell surface glycoprotein CD8 alpha chain, T-cell surface glycoprotein CD8 beta chain, T-cell surface glycoprotein Lyt-2, T-cell surface glycoprotein Lyt-3, T-cell surface molecule, T-lymphocyte differentiation antigen T8/Leu-2, type I transmembrane glycoprotein
Gene Symbols
Cd8a, Cd8b1
Primary or Secondary
Primary
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Clone
53-6.7
Applications
Flow Cytometry
Conjugate
Brilliant Violet 605
Host Species
Rat
Target Species
Mouse
Gene Accession No.
P01731, P10300
Gene ID (Entrez)
12525, 12526
Isotype
IgG2a κ
Purification Method
Affinity chromatography
Gene
Cd8a
Related Products
Description
- Cluster of differentiation 8 (CD8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation
- CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8alpha and CD8beta, where it functions as a co-receptor, along with T cell receptor (TCR), for major histocompatibilty complex class I (MHC-I) molecules; whereas its counterpart, CD4, acts as a co-receptor for MHC-II molecules
- CD8 exists on the cell surface, where the CD8alpha chain is essential for binding to MHC-I
- CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8alpha
- Ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), triggers the recruitment of lymphocyte-specific protein tyrosine kinase (Lck), which leads to lymphokine production, motility and cytotoxic T lymphocyte (CTL) activation
- Once activated, CTLs play a crucial role in the clearance of pathogens and tumor cells
- Differentiation of naive CD8+ T cells into CTLs is strongly enhanced by IL-2, IL-12 and TGF-beta1.
Compare Similar Items
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Antigen: CD8a
Concentration: 0.2 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with BSA and 0.09% sodium azide, pH 7.2
Gene Alias: BB154331, CD8, CD8 alpha, CD8 alpha chain, CD8 alpha chain precursor, CD8 antigen, CD8 antigen 32 kDa chain, CD8 antigen 37 kDa chain, CD8 antigen alpha polypeptide, CD8 antigen alpha protein, CD8 antigen alpha protein precursor, CD8 antigen alpha-chain, CD8 antigen beta polypeptide, CD8 antigen beta polypeptide precursor, CD8 antigen beta-chain, CD8 antigen, alpha chain, CD8 antigen, alpha polypeptide, CD8 antigen, alpha polypeptide (p32), CD8 antigen, alpha-chain, CD8 antigen, beta chain, CD8 antigen, beta chain 1, CD8 antigen, beta polypeptide, CD8 antigen, beta polypeptide 1 (p37), CD8 antigen, beta-chain, CD8 beta, CD8 beta chain, CD8 beta-2, CD8a, CD8A antigen alpha, CD8a molecule, CD8A, T-cell surface glycoprotein, CD8alpha, CD8B, CD8b antigen, CD8b molecule, CD8b molecule pseudogene, Cd8b1, CD8beta, CD8BP, fCD8, LEU2, Leu-2, Leu2 T-lymphocyte antigen, leu-2a, Ly-2, LY3, Ly-3, Ly-35, Ly-B, Ly-C, Lymphocyte antigen 3, Lyt2, Lyt-2, Lyt-2.1 lymphocyte differentiation antigen (AA at 100), Lyt3, Lyt-3, MAL, membrane glycoprotein, membrane protein, OKT8 T-cell antigen, OX-8 membrane antigen, p32, P37, RHACD8-4, T cell co-receptor, T lymphocyte surface glycoprotein beta chain, T8 T-cell antigen, T-cell antigen Leu2, T-cell membrane glycoprotein Ly-3, T-cell surface glycoprotein, T-cell surface glycoprotein CD8 alpha chain, T-cell surface glycoprotein CD8 beta chain, T-cell surface glycoprotein Lyt-2, T-cell surface glycoprotein Lyt-3, T-cell surface molecule, T-lymphocyte differentiation antigen T8/Leu-2, type I transmembrane glycoprotein
Gene Symbols: Cd8a, Cd8b1
Primary or Secondary: Primary
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Clone: 53-6.7
Applications: Flow Cytometry
Conjugate: Brilliant Violet 605
Host Species: Rat
Target Species: Mouse
Gene Accession No.: P01731, P10300
Gene ID (Entrez): 12525, 12526
Isotype: IgG2a κ
Purification Method: Affinity chromatography
Gene: Cd8a
Antigen: CD38
Concentration: 0.2 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with BSA and 0.09% sodium azide, pH 7.2
Gene Alias: 2'-phospho-ADP-ribosyl cyclase, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase, 2'-phospho-cyclic-ADP-ribose transferase, ADPRC 1, ADPRC1, ADP-ribosyl cyclase 1, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, Cd38, CD38 antigen, CD38 antigen (ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase), CD38 antigen (p45), CD38 antigen p45, CD38 molecule, CD38H, Cd38-rs1, cluster of differentiation 38, cyclic ADP-ribose hydrolase 1, ecto-nicotinamide adenine dinucleotide glycohydrolase, I-19, NAD(+) nucleosidase, NAD+ nucleosidase, NIM-R5 antigen, T10
Gene Symbols: CD38
Primary or Secondary: Primary
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Clone: 90
Applications: Flow Cytometry
Conjugate: Brilliant Violet 605
Host Species: Rat
Target Species: Mouse
Gene Accession No.: P56528
Gene ID (Entrez): 12494
Isotype: IgG2a κ
Purification Method: Affinity chromatography
Gene: CD38
Antigen: CD4
Concentration: 0.2 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with BSA and 0.09% sodium azide, pH 7.2
Gene Alias: Activation B7-1 antigen, B7, B7.1, B7-1, BB1, B-lymphocyte activation antigen B7, CD28LG, CD28LG1, CD4, CD4 antigen, CD4 antigen (p55), CD4 antigen p55, Cd4 molecule, CD4 precursor, CD4 receptor, CD4, allele 1, cd4a, CD4mut, CD80, CD80 antigen (CD28 antigen ligand 1, B7-1 antigen), CD80 molecule, cell surface glycoprotein CD4, costimulatory factor CD80, costimulatory molecule variant IgV-CD80, CTLA-4 counter-receptor B7.1, fCD4, L3T4, LAB7, Leu-3, Ly-4, lymphocyte antigen CD4, lymphocyte antigen CD4 precursor, membrane protein, p55, T-cell differentiation antigen L3T4, T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4, T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4), T-lymphocyte activation antigen CD80, W3/25, W3/25 antigen
Gene Symbols: CD4
Primary or Secondary: Primary
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Clone: GK1.5
Applications: Flow Cytometry
Conjugate: Brilliant Violet 480
Host Species: Rat
Target Species: Mouse
Gene Accession No.: P06332
Gene ID (Entrez): 12504
Isotype: IgG2b κ
Purification Method: Affinity chromatography
Gene: CD4