3855920

Ran Mouse, Unlabeled, Clone: 20, BD

Mouse Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

Ran

Concentration

250μg/mL

Classification

Monoclonal

Host Species

Mouse

Research Discipline

Cell Biology

Formulation

Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Isotype

IgG2a

Purification Method

Affinity Purified

Clone

20

Applications

Western Blot

Conjugate

Unconjugated

Regulatory Status

RUO

Target Species

Canine, Chicken, Human, Mouse, Rat

Immunogen

Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Primary or Secondary

Primary

Content And Storage

Store undiluted at -20°C.

Description

  • Ran is a highly conserved GTPase that is ubiquitously expressed
  • At steady-state, 80-90% of cellular Ran is located in the nucleus, with the remainder in the cytoplasm
  • The human TC4/Ran cDNA was originally isolated based on the predicted homology of its encoded protein product to Ras
  • Unlike other members of the Ras superfamily, Ran does not appear to contain signals for lipid modification, nor does it appear to show membrane localization
  • Ran has been implicated in a number of cellular processes such as the initiation of DNA replication, entry into and exit from mitosis and in nuclear RNA and protein transport through the nuclear pore complex
  • A number of Ran binding proteins have been identified
  • One of the smaller proteins identified is a 28kDa cytosolic molecule known as RanBP1
  • The GTP-bound state of Ran is stabilized through its binding to RanBP1.

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Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

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Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

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Store undiluted at -20°C.

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Store undiluted at -20°C.

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Isotype:
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