FADD Mouse anti-Human, Unlabeled, Clone: 1, BD

Description

• During apoptosis, cells exhibit morphological signs of the death process: cell shrinkage, membrane blebbing, and chromatin condensation
• The role of the cell surface cytokine receptor, Fas (Apo-1, CD95), in apoptosis has been well characterized
• The tumor necrosis factor receptor (TNF-R) can trigger cell death, as well as various other responses
• Data suggested that Fas and TNF-R affect a common target in the cell death pathway
• This target has been identified as FADD, a novel protein that contains a death domain homologous to the death domains of Fas and TNF-R1
• FADD specifically binds to Fas, an association mediated by their homologous death domains
• Overexpression of FADD induces apoptosis that is inhibited by CrmA, a poxvirus protein that blocks both Fas- and TNF-induced cell death
• Thus, FADD is a central element of the Fas-mediated cell death pathway
• This antibody is routinely tested by western blot analysis
• Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.