3856086

Gephyrin Mouse, Unlabeled, Clone: 45, BD

Mouse Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

Gephyrin

Concentration

250μg/mL

Classification

Monoclonal

Host Species

Mouse

Research Discipline

Cell Biology

Formulation

Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Isotype

IgG1

Purification Method

Affinity Purified

Clone

45

Applications

Western Blot

Conjugate

Unconjugated

Regulatory Status

RUO

Target Species

Chicken, Human, Mouse, Rat

Immunogen

Rat Gephyrin aa. 569-726

Primary or Secondary

Primary

Content And Storage

Store undiluted at -20°C.

Description

  • The sub-membraneous region of the postsynaptic neuron is an intricate network of cytoskeletal elements generally known as the postsynaptic density
  • It is thought that this elaborate cytoskeletal region is critical for receptor targeting, clustering, and efficient signal input
  • Gephyrin, a 93kDa protein, was identified as a result of its ability to bind to polymerized tubulin (microtubules)
  • Although expressed in all tissues, gephyrin mRNA is found most abundantly in brain
  • Alternative splicing produces at least five different mRNAs
  • Gephyrin colocalizes and interacts with the glycine receptor at the postsynaptic density
  • It is possible that Gephyrin acts as an anchor between the glycine receptor and microtubules
  • Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

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