3856112

SHP2 Mouse, Unlabeled, Clone: 79, BD

Mouse Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

SHP2

Concentration

250μg/mL

Classification

Monoclonal

Host Species

Mouse

Research Discipline

Cell Biology

Formulation

Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Isotype

IgG1

Purification Method

Affinity Purified

Description

PTP1D, Syp, SHPTP2 and PTP2C

Clone

79

Applications

Western Blot

Conjugate

Unconjugated

Regulatory Status

RUO

Target Species

Canine, Chicken, Frog, Human, Mouse, Rat

Immunogen

Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Primary or Secondary

Primary

Content And Storage

Store undiluted at -20°C.

Description

  • SHP2 (also known as PTP1D, Syp, SHPTP2 and PTP2C) is a member of the cytosolic class of protein-tyrosine phosphatases (PTPs)
  • SHP2 has been reported to contain two SH2 domains where both SH2 domains are N-terminal to the PTP catalytic domain
  • The expression of SHP2 has been reported to be highest in brain, heart, and kidney
  • The PTPs are thought to function with other protein-tyrosine kinases to maintain intracellular protein phosphotyrosine homeostasis and cell cycle progression
  • The presence ofSH2 domains in SHP2 (PTP1D) has prompted speculation that binding to specific phosphorylated tyrosine residues is key to its function
  • SHP2 (PTP1D) is tyrosine- phosphorylated and activated in response to stimulation with EGF or PDGF.

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Store undiluted at -20°C.

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