PCNA Mouse, Unlabeled, Clone: 24, BD

Description

• Progression of the mammalian cell cycle is regulated in two different ways: 1) phosphorylation and dephosphorylation of key proteins, 2) synthesis and degradation of regulatory factors
• The Proliferating Cell Nuclear Antigen (PCNA) was initially identified as a nuclear antigen in proliferating cells and was subsequently described as a subunit for DNA polymerase δ
• Human PCNA is 262 amino acids with an apparent molecular weight of 36kDa
• PCNA protein levels peak during the S-phase of the cell cycle, at which time it forms a complex with the p21 inhibitor
• PCNA is almost undetectable in other phases of the cycle
• Because of its unique expression, PCNA has been extensively used in studies associating the prognosis of tumor progression and neoplastic proliferation
• Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting