Annexin VII Mouse anti-Human, Unlabeled, Clone: 5, BD

Description

• Annexin VII, also known as synexin, is a member of the Annexin family characterized by Ca 2 + dependent phospholipid binding
• Annexins have a four-fold internal repeat of about 70 amino acids that contains the Ca 2 + -binding sites
• They also have a regulatory NH2-terminal region of 30-40 amino acids
• Annexin VII mRNA has been detected in many tissues and is most abundant in brain, heart, skeletal muscle, and lung
• Annexin VII mRNA exhibits a tissue dependent polymorphism due to alternative splicing which results in two different isoforms of 47kDa and 51kDa
• In vitro, Annexin VII aggregates chromaffin granules and enhances membrane fusion in a Ca 2 + and GTP-dependent manner
• Although the physiological role of Annexin VII is not completely understood, it is believed to influence and regulate Ca 2 + dependent events such as secretion at the plasma membrane
• Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting