3856071

NuMA Mouse, Unlabeled, Clone: 22, BD

Mouse Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

NuMA

Concentration

250μg/mL

Classification

Monoclonal

Host Species

Mouse

Research Discipline

Cell Biology

Formulation

Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Isotype

IgM

Purification Method

Affinity Purified

Clone

22

Applications

Western Blot

Conjugate

Unconjugated

Regulatory Status

RUO

Target Species

Canine, Chicken, Human, Mouse, Rat

Immunogen

Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

Primary or Secondary

Primary

Content And Storage

Store undiluted at -20°C.

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Description

  • NuMA (Nuclear Mitotic Apparatus protein) is a 2115 amino acid protein with a coiled-coil structure similar to that of myosins and intermediate filaments
  • Indirect immunofluorescence assays indicate that NuMA's localization is very dynamic
  • During interphase, NuMA is in the nucleus and during mitosis it moves to the polar regions of the mitotic spindle
  • NuMA is a very abundant phosphoprotein and antibodies to this protein are often found in patients with autoimmune diseases
  • Although NuMA is thought to be a structural component of the nucleus, the precise cellular function for this protein is still unknown
  • Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

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