JNK/SAPK1 Mouse, Unlabeled, Clone: 37, BD

Description

• The Ras signaling pathway links the signals from growth factor receptors with the activation of the MAPK kinase cascade of phosphorylation leading to cell growth and differentiation
• External stimuli, such as endotoxins, UV irradiation, heat, and hyperosmolarity, induce an array of cellular responses that culminate with gene expression, ultimately dictating an adaptation to the new environment
• The ultimate cellular response to environmental stress is cell death or apoptosis
• This pathway is regulated by Rac1 and Cdc42 which link Jun Kinases (JNKs), such as p38
• JNK is a c-Jun kinase that was also identified as SAPK1 and MAPKp49
• JNK contains homology with the MAP/ERK family of kinases, and contains an N-terminal ATP-binding site and two autophosphorylation “TXY” sites
• JNKK1/MEKK4/SEK1 is a dual-specificity kinase activated by conditions of cellular stress, such as heat shock and hyperosmolarity
• JNKK1 phosphorylates JNK and p38 but not the ERK MAP kinases
• Active JNK and p38 phosphorylate multiple transcription factors that induce expression of genes, such as proinflammatory cytokines.