Stat5 Mouse, Unlabeled, Clone: 89, BD

Description

• Stat5, also known as mammary gland factor (MGF) has been shown to play a critical role in the lactogenic hormone response and has been well characterized in mammary epithelial cells
• The SH3 domain of MGF shows extensive homology with the SH2 domains of Stat1 and Stat2
• This homology has led to its classification as a member of the Stat family
• The Stat proteins function both as cytoplasmic signal transducers and as activators of transcription
• Stat (Signal transducer and activators of transcription) proteins are critical mediators of the biologic activity of cytokines, including interleukins, interferons, erythropoietin, and growth factors
• Ligand-receptor interaction leads to activation of constitutively associated JAK family kinases and subsequent recruitment and activation of Stat proteins by tyrosine phosphorylation
• Active Stat proteins then move to the nucleus to promote transcription of cytokine-inducible genes
• Stat5a has been shown to be involved in lactogenesis and mammary development, while Stat5b has been shown to be involved in growth hormone signaling and to play a role in liver gene expression
• Stat5 activity is tightly regulated throughout gestation, lactation, and post-lactation.