3967318
Btk Mouse anti-Human, Unlabeled, Clone: 53/BTK, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Btk
Concentration
250μg/mL
Classification
Monoclonal
Host Species
Mouse
Research Discipline
Cell Biology
Formulation
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype
IgG2a
Purification Method
Affinity Purified
Clone
53/BTK
Applications
Western Blot
Conjugate
Unconjugated
Regulatory Status
RUO
Target Species
Human
Immunogen
Human N-Terminal Btk aa. 2-172 Recombinant Protein
Primary or Secondary
Primary
Content And Storage
Store undiluted at -20°C.
Description
- Bruton's tyrosine kinase (Btk) is a nonreceptor tyrosine kinase whose function is critical for proper B cell development and signaling
- It is a member of the Tec family of kinases which includes Tec and Itk
- In addition to an N-terminal pleckstrin homology (PH) domain, the Tec proteins contain Src homology domains 2 and 3 (SH2 and SH3) and a stretch of 60-80 amino acids between the PH and SH3 domains termed the Tec homology domain
- The activity of Btk is regulated by Src-mediated phosphorylation of the kinase domain at tyrosine 551
- This event induces Btk kinase activity and subsequent autophosphorylation at tyrosine 223 in the SH3 domain
- Phosphorylated Btk then associates with the cell membrane via the interaction of the PH domain with phosphatidylinositol 3, 4, 5-triphosphate
- The PH domain is essential for proper activation and function of Btk
- A mutation in the PH domain results in Xid, murine X-linked immunodeficiency, and human X-linked agammaglobulinemia
- Host Species: Mouse Clone: 53 Isotype: IgG2a Species Reactivity: Human Immunogen: Human N-Terminal Btk aa
- 2-172 Recombinant Protein Formula Weight [Chemical]: 77kDa Immunofluorescence, Western Blotting
Compare Similar Items
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Antigen: Btk
Concentration: 250μg/mL
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Cell Biology
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype: IgG2a
Purification Method: Affinity Purified
Clone: 53/BTK
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Human
Immunogen: Human N-Terminal Btk aa. 2-172 Recombinant Protein
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
Btk
Concentration:
250μg/mL
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Cell Biology
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype:
IgG2a
Purification Method:
Affinity Purified
Clone:
53/BTK
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Human
Immunogen:
Human N-Terminal Btk aa. 2-172 Recombinant Protein
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.
Antigen: DLP1
Concentration: 250μg/mL
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Cell Biology
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype: IgG1
Purification Method: Affinity Purified
Clone: 8
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Canine, Human, Mouse, Rat
Immunogen: Rat DLP1 aa. 601-722
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
DLP1
Concentration:
250μg/mL
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Cell Biology
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype:
IgG1
Purification Method:
Affinity Purified
Clone:
8
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Canine, Human, Mouse, Rat
Immunogen:
Rat DLP1 aa. 601-722
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.
Antigen: DLP1
Concentration: 250μg/mL
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Cell Biology
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype: IgG1
Purification Method: Affinity Purified
Clone: 8
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Canine, Human, Mouse, Rat
Immunogen: Rat DLP1 aa. 601-722
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
DLP1
Concentration:
250μg/mL
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Cell Biology
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype:
IgG1
Purification Method:
Affinity Purified
Clone:
8
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Canine, Human, Mouse, Rat
Immunogen:
Rat DLP1 aa. 601-722
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.
Antigen: Ki-67
Concentration: __
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Cell Biology
Formulation: __
Isotype: IgG1 κ
Purification Method: Affinity Purified
Clone: B56
Applications: __
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Human, Mouse, Rat, Rhesus Monkey
Immunogen: Human Ki-67
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C
Antigen:
Ki-67
Concentration:
__
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Cell Biology
Formulation:
__
Isotype:
IgG1 κ
Purification Method:
Affinity Purified
Clone:
B56
Applications:
__
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Human, Mouse, Rat, Rhesus Monkey
Immunogen:
Human Ki-67
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C