3969095

CD19 Rat anti-Mouse, APC-H7, Clone: 1D3, BD

Rat Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

CD19

Concentration

0.2mg/mL

Classification

Monoclonal

Host Species

Rat

Research Discipline

Immunology

Formulation

Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.

Isotype

IgG2a κ

Purification Method

Affinity Purified

Clone

1D3

Applications

Flow Cytometry

Conjugate

APC-H7

Regulatory Status

RUO

Target Species

Mouse

Immunogen

Mouse CD19 Transfected Cell Line

Primary or Secondary

Primary

Content And Storage

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

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Description

  • The 1D3 antibody reacts with CD19, a B lymphocyte-lineage differentiation antigen
  • CD19, a 95kDa transmembrance glycoprotein, is a member of the immunoglobulin superfamily and is expressed throughout B-lymphocyte development from the pro-B cell through the mature B-cell stages
  • Terminally differentiated plasma cells do not express CD19
  • On the surface of mature B cells, the CD19 molecule associates with CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to promote cellular activation
  • Studies with CD19-deficient mice have suggested that the level of CD19 expression affects the generation and maturation of B cells in the bone marrow and periphery
  • B-1 lineage B cells, also known as CD5+ B cells, are drastically reduced or absent in CD19-deficient mice
  • Increased levels of CD19 expression correlate with increased frequencies of peritonal and splenic B-1 cells and reduced numbers of conventional B lymphocytes in the periphery
  • CD19 participates in B-lymphocyte development, B-cell activation, maturation of memory B cells and regulation of tolerance
  • CD19 has also been detected on peritoneal mast cells, co-localized with CD21/CD35, and it is proposed to play a role in complement-mediated mast-cell activation
  • Host Species: Rat Clone: 1D3 Isotype: IgG2a κ Species Reactivity: Mouse Immunogen: Mouse CD19 Transfected Cell Line Flow Cytometry, Intracellular Staining

Compare Similar Items

Show Difference

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Fischer Scientific

3969095

Rat Monoclonal Antibody...


Antigen:
CD19

Concentration:
0.2mg/mL

Classification:
Monoclonal

Host Species:
Rat

Research Discipline:
Immunology

Formulation:
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.

Isotype:
IgG2a κ

Purification Method:
Affinity Purified

Clone:
1D3

Applications:
Flow Cytometry

Conjugate:
APC-H7

Regulatory Status:
RUO

Target Species:
Mouse

Immunogen:
Mouse CD19 Transfected Cell Line

Primary or Secondary:
Primary

Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

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Antigen:
CD19

Concentration:
__

Classification:
Monoclonal

Host Species:
Mouse

Research Discipline:
Immunology

Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.

Isotype:
IgG1 κ

Purification Method:
Affinity Purified

Clone:
SJ25C1

Applications:
Flow Cytometry

Conjugate:
APC-H7

Regulatory Status:
RUO

Target Species:
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Immunogen:
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Primary or Secondary:
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Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

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Antigen:
CD19

Concentration:
0.2mg/mL

Classification:
Monoclonal

Host Species:
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Research Discipline:
Immunology

Formulation:
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.

Isotype:
IgG2a κ

Purification Method:
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Clone:
1D3

Applications:
Flow Cytometry

Conjugate:
Violet Fluor 450 (V450)

Regulatory Status:
RUO

Target Species:
Mouse

Immunogen:
Mouse CD19 Transfected Cell Line

Primary or Secondary:
Primary

Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

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Rat Monoclonal Antibody...


Antigen:
CD19

Concentration:
0.2mg/mL

Classification:
Monoclonal

Host Species:
Rat

Research Discipline:
Immunology

Formulation:
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.

Isotype:
IgG2a κ

Purification Method:
Affinity Purified

Clone:
1D3

Applications:
Flow Cytometry

Conjugate:
Violet Fluor 450 (V450)

Regulatory Status:
RUO

Target Species:
Mouse

Immunogen:
Mouse CD19 Transfected Cell Line

Primary or Secondary:
Primary

Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.