CD38 Mouse anti-Human, Brilliant Violet 421, Clone: HIT2, BD

Description

• The HIT2 monoclonal antibody specifically binds to CD38
• CD38 is a 45 kDa type II single-chain transmembrane glycoprotein present on thymocytes, activated T cells and terminally differentiated B cells (plasma cells)
• Other reactive cells include monocytes, macrophages, dendritic cells and some epithelial cells
• The CD38 antigen acts as an ectoenzyme that catalyzes the synthesis and hydrolysis of a Ca++ mobilizing agent, cyclic ADP-ribose
• This intracellular calcium plays an important role in cell signaling pathways
• Reports describe CD38 as participating in adhesion with CD31, immunoregulatory functions involving signal transduction leading to cell growth, apoptosis, and differentiation
• The antibody was conjugated to Brilliant Violet 421 and has been developed in collaboration with Sirigen
• With an Ex Max of 407-nm and Em Max at 421-nm, Brilliant Violet 421 can be excited by the violet laser and detected in the standard Pacific Blue filter set (eg, 450/50-nm filter)
• Brilliant Violet 421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue conjugates
• Host Species: Mouse Clone: HIT2 Isotype: IgG1, κ Species Reactivity: Human Flow Cytometry