Epredia™ Cystic Fibrosis Transmembrane Regulator (CFTR) Ab-3 Mouse Monoclonal Antibody, 200μg/mL, BSA and azide

Description

• CFTR (cystic fibrosis transmembrane conductance regulator) is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain
• It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates
• The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts
• CFTR is a valuable marker of human pancreatic duct cell development and differentiation
• Host Species: Mouse Clone: L12B4 Isotype: IgG1 Species Reactivity: Human, Mouse and Rat
• Others not known
• Epitope: aa 386-412 Immunogen: Recombinant protein encoding NBF1 domain of human CFTR Molecular Weight: 165-170 kDa Positive Control: Pancreas Cellular Localization: Membrane Recommended for: Western Blotting (Not verified) Immunofluorescence Immunoprecipitation Note: USA: RUO; Int'l: RUO