4561450
Epredia™ Lab Vision™ Retinoblastoma (Rb) Ab-1 Mouse Monoclonal Antibody, 200μg/mL, biotinylated, BSA and azide
Provide accurate, reproducible results with the Epredia™ Retinoblastoma (Rb) Ab-1, Mouse Monoclonal Antibody.
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Antigen
Retinoblastoma (Rb) Ab-1
Applications
Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Host Species
Mouse
Research Discipline
Cancer and Tumor Biology
Immunogen
Recombinant human Rb protein
Primary or Secondary
Primary
Clone
1F8; same as Rb1
Classification
Monoclonal
Regulatory Status
RUO
Target Species
Human
Isotype
IgG1
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Description
- Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA
- It is phosphorylated on serine and threonine, but not on tyrosine residues
- It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E
- Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth
- Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia
- Host Species: Mouse Clone: 1F8; same as Rb1 Isotype: IgG1 Species Reactivity: Human
- Does not react with mouse and rat
- Others not known
- Epitope: aa 703-722 Immunogen: Recombinant human Rb protein Molecular Weight: 105kDa Positive Control: Ls174T, HT29, HUVEC cells; Normal colon, Breast CA and colon CA Cellular Localization: Nuclear Ab-1 specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells
- It reacts with hyperphosphorylated and un (under) phosphorylated form of Rb protein
- It shows no cross reaction with p107 and p130
- Recommended for: Immunohistochemistry (Formalin/paraffin) Western Blotting Immunofluorescence Immunoprecipitation (Native and denatured) Flow Cytometry Note: USA: RUO; Int'l: RUO
Compare Similar Items
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Antigen: Retinoblastoma (Rb) Ab-1
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Host Species: Mouse
Research Discipline: Cancer and Tumor Biology
Immunogen: Recombinant human Rb protein
Primary or Secondary: Primary
Clone: 1F8; same as Rb1
Classification: Monoclonal
Regulatory Status: RUO
Target Species: Human
Isotype: IgG1
Antigen:
Retinoblastoma (Rb) Ab-1
Applications:
Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Host Species:
Mouse
Research Discipline:
Cancer and Tumor Biology
Immunogen:
Recombinant human Rb protein
Primary or Secondary:
Primary
Clone:
1F8; same as Rb1
Classification:
Monoclonal
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG1
Antigen: __
Applications: __
Host Species: __
Research Discipline: __
Immunogen: __
Primary or Secondary: __
Clone: __
Classification: __
Regulatory Status: __
Target Species: __
Isotype: __
Antigen:
__
Applications:
__
Host Species:
__
Research Discipline:
__
Immunogen:
__
Primary or Secondary:
__
Clone:
__
Classification:
__
Regulatory Status:
__
Target Species:
__
Isotype:
__
Antigen: SV40 Large T Antigen Ab-1
Applications: Immunofluorescence, Immunoprecipitation, Western Blot
Host Species: Mouse
Research Discipline: Infectious Disease
Immunogen: SV40 transformed mouse line B4
Primary or Secondary: Primary
Clone: PAb101; same as clone 412
Classification: Monoclonal
Regulatory Status: RUO
Target Species: Simian virus 40 (SV40)
Isotype: __
Antigen:
SV40 Large T Antigen Ab-1
Applications:
Immunofluorescence, Immunoprecipitation, Western Blot
Host Species:
Mouse
Research Discipline:
Infectious Disease
Immunogen:
SV40 transformed mouse line B4
Primary or Secondary:
Primary
Clone:
PAb101; same as clone 412
Classification:
Monoclonal
Regulatory Status:
RUO
Target Species:
Simian virus 40 (SV40)
Isotype:
__
Antigen: Synaptophysin (Neuroendocrine Marker)
Applications: __
Host Species: Rabbit
Research Discipline: Neuroscience
Immunogen: A synthetic peptide of human synaptophysin
Primary or Secondary: Primary
Clone: SP11
Classification: Monoclonal
Regulatory Status: IVD
Target Species: __
Isotype: __
Antigen:
Synaptophysin (Neuroendocrine Marker)
Applications:
__
Host Species:
Rabbit
Research Discipline:
Neuroscience
Immunogen:
A synthetic peptide of human synaptophysin
Primary or Secondary:
Primary
Clone:
SP11
Classification:
Monoclonal
Regulatory Status:
IVD
Target Species:
__
Isotype:
__