CD103 (Integrin alpha E) Monoclonal Antibody (2E7), APC-eFluor™ 780, eBioscience™, Invitrogen™

Description

• The BMA12 monoclonal antibody reacts with mouse CD100, also known as Sema4D
• Sema4D/CD100 is a 150kDa transmembrane protein expressed constitutively on T cells and is involved in the activation of B cells through its interaction with CD72
• Interaction of these two proteins diminishes the negative signaling normally effected by CD72
• CD100 is already expressed strongly on resting T cells and somewhat weakly on B cells, but activation upregulates expression on both cell types
• Antigen expression has been reported in Spleen, thymus and l CD103 (ITGAE, Integrin alpha E) is molecule that is expressed on mucosa-associated T lymphocytes and activated cells and on subet of TGF beta -1 cells
• In particular, CD103 includes a 150kDa alpha chain and a 120kDa beta chain
• CD103 is expressed by 0.5 to 2% of resting lymphocytes in peripheral blood and lymphoid organs
• CD103 antibody stains a few bone marrow cells and, rarely, peripheral blood lymphocytes
• CD103 is part of the integrin family which are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain
• ITGAE encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains
• In combination with the beta 7 integrin, CD103 protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen
• CD103 is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation
• Diseases associated with CD103 dysfunction include hairy cell leukemia and splenic marginal zone lymphoma.