50-101-19

Perforin Monoclonal Antibody (dG9 (delta G9)), FITC, eBioscience™, Invitrogen™

Manufacturer: Fischer Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 50-101-19-Each-of-1 In Stock ₹ 11,978.40

50-101-19 - Each of 1

₹ 11,978.40

In Stock

Quantity

1

Base Price: ₹ 11,978.40

GST (18%): ₹ 2,156.112

Total Price: ₹ 14,134.512

Antigen

Perforin

Classification

Monoclonal

Concentration

5 μL/Test

Formulation

PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2

Gene Accession No.

P14222

Gene Symbols

PRF1

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

396595, 5551

Content And Storage

4° C, store in dark, DO NOT FREEZE!

Form

Liquid

Applications

Flow Cytometry, Immunohistochemistry

Clone

dG9 (delta G9)

Conjugate

FITC

Gene

PRF1

Gene Alias

Cyta; Cytolysin; FLH2; HPLH2; lymphocyte pore forming protein; lymphocyte pore-forming protein; OMAK; OTTHUMP00000019759; P1; perforin 1; perforin 1 (pore forming protein); Perforin1; perforin-1; Pfn; PFN1; Pfp; PGFL; PIGF; PIGF-2; PLGF; pore forming protein; pore-forming protein; PRF1; Prf-1; PRF1 (pore forming protein 1); RATCYTA; RP11-710A11.3

Host Species

Mouse

Quantity

25 Tests

Primary or Secondary

Primary

Target Species

Human, Porcine

Product Type

Antibody

Isotype

IgG2b κ

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Description

  • Description: The dG9 antibody clone reacts with human perforin (pore-forming protein, pfp)
  • Perforin is one of the cytolytic mediators present in the cytoplasmic granules of cytotoxic T lymphocytes (CTL) and natural killer cells (NK)
  • Perforin is involved in the killing function by CTLs and NKs and has an important role in the immune response against tumors and virus infections
  • Applications Reported: This dG9 (delta G9) antibody has been reported for use in intracellular staining followed by flow cytometric analysis, and immunohistochemical staining
  • Applications Tested: This dG9 (delta G9) antibody has been tested by intracellular flow cytometric analysis of normal human peripheral blood cells
  • This can be used at 5 μL (0.125 μg) per test
  • A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
  • Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
  • Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser
  • Filtration: 0.2 μm post-manufacturing filtered
  • Perforin is one of the major cytolytic proteins of cytolytic granules
  • Perforin is a cytolytic mediator and is stored in and released by cytoplasmic granules
  • Moreover, perforin is involved in immune defense against tumors and virus infections as mediated by cytotoxic lymphocytes
  • Perforin is a 555 amino acid protein with a 21 amino acid signal peptide, and has a molecular weight of 70 to 75 kD
  • Perforin is a pore forming protein with a mechanism of transmembrane channel formation similar to C9, and homology between perforin and C9 have been demonstrated
  • Studies show that perforin is expressed only in killer cell lines and not in helper T lymphocytes or other tumor cells tested
  • Perforin is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis
  • Defects in the perforin gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood
  • Alternative splicing results in multiple transcript variants of perforin.

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Fischer Scientific

50-101-19

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Antigen:
Perforin

Classification:
Monoclonal

Concentration:
5 μL/Test

Formulation:
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2

Gene Accession No.:
P14222

Gene Symbols:
PRF1

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
396595, 5551

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Form:
Liquid

Applications:
Flow Cytometry, Immunohistochemistry

Clone:
dG9 (delta G9)

Conjugate:
FITC

Gene:
PRF1

Gene Alias:
Cyta; Cytolysin; FLH2; HPLH2; lymphocyte pore forming protein; lymphocyte pore-forming protein; OMAK; OTTHUMP00000019759; P1; perforin 1; perforin 1 (pore forming protein); Perforin1; perforin-1; Pfn; PFN1; Pfp; PGFL; PIGF; PIGF-2; PLGF; pore forming protein; pore-forming protein; PRF1; Prf-1; PRF1 (pore forming protein 1); RATCYTA; RP11-710A11.3

Host Species:
Mouse

Quantity:
25 Tests

Primary or Secondary:
Primary

Target Species:
Human, Porcine

Product Type:
Antibody

Isotype:
IgG2b κ

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Apexbio Technology LLC

50-101-1922

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50-101-1929

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