SOX11 Monoclonal Antibody (SOX11-C1), eBioscience™, Invitrogen™

Description

• Description: The monoclonal antibody SOX11-C1 (C1) recognizes human Sox11
• The transcription factor Sox11 is a member of the SOX (sex determining region Y-related HMG (High Mobility Group) Box) family of proteins
• Under normal conditions Sox11 is expressed in the developing central nervous system during embryogenesis and has sequence homology to Sox4
• Sox11 plays a role in neuronal maturation and epithelial-mesenchymal interactions and is required for the survival of neuronal and mesenchymal progenitor cells
• Sox11 is expressed in mantle cell lymphoma (MCL) and in subsets of hairy cell leukemias, Burkitt lymphomas, and B cell lymphoblastic leukemias, but is not expressed in other B cell lymphomas or in normal B lymphocytes
• Sox11 is also expressed in epithelial ovarian cancer and gliomas
• Applications Reported: This SOX11-C1 antibody has been reported for use in flow cytometric analysis, western blotting, immunohistochemical staining of formalin-fixed paraffin embedded tissue sections, and immunocytochemistry
• Applications Tested: This SOX11-C1 antibody has been tested by immunohistochemistry of formalin-fixed paraffin embedded tissue using low or high pH antigen retrieval
• The antibody can be used at less than or equal to 5 μg/mL
• This SOX11-C1 antibody has been tested by immunocytochemistry of fixed and permeabilized cells and can be used at less than or equal to 5 μg/mL
• This intronless gene encodes a member of the SOX family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate
• The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins
• The protein may function in the developing nervous system and play a role in tumorigenesis.