50-112-4862

ROR gamma (t) Monoclonal Antibody (B2D), PE-eFluor™ 610, eBioscience™, Invitrogen™

Manufacturer: Fischer Scientific

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Pack Size SKU Availability Price
Each of 1 50-112-4862-Each-of-1 In Stock ₹ 19,507.68

50-112-4862 - Each of 1

₹ 19,507.68

In Stock

Quantity

1

Base Price: ₹ 19,507.68

GST (18%): ₹ 3,511.382

Total Price: ₹ 23,019.062

Antigen

ROR gamma (t)

Classification

Monoclonal

Concentration

0.2 mg/mL

Formulation

PBS with 0.09% sodium azide; pH 7.2

Gene Accession No.

P51450

Gene Symbols

Rorc

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

19885

Content And Storage

4° C, store in dark, DO NOT FREEZE!

Form

Liquid

Applications

Flow Cytometry

Clone

B2D

Conjugate

PE-eFluor 610

Gene

Rorc

Gene Alias

EGK_01272; IMD42; MGC129539; NR1F3; nuclear receptor ROR-gamma; Nuclear receptor RZR-gamma; nuclear receptor subfamily 1 group F member 3; RAR related orphan receptor C; RAR-related orphan nuclear receptor variant 2; RAR-related orphan receptor C; RAR-related orphan receptor C, isoform a; RAR-related orphan receptor gamma; retinoic acid-binding receptor gamma; retinoid-related orphan receptor gamma; retinoid-related orphan receptor-gamma; ROR Gamma; ROR gamma t; Rorc; Rorg; RORgamma; RORgt; RP11-98D18.11-001; RZRG; RZR-GAMMA; Thor; Thymus orphan receptor; TOR

Host Species

Rat

Quantity

25 μg

Primary or Secondary

Primary

Target Species

Mouse

Product Type

Antibody

Isotype

IgG1 κ

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Description

  • Description: The B2D monoclonal antibody reacts with the mouse ROR gamma (t) protein
  • ROR gamma is a member of the retinoic acid-related orphan receptor (ROR) family, which also includes ROR alpha and ROR beta
  • ROR family proteins are ligand-dependent transcription factors that play roles in multiple physiological processes
  • ROR gamma is expressed in several tissues including liver, lung, muscle, heart and kidney
  • Furthermore, it was discovered that alternative transcription results in the expression of an isoform, ROR gamma t, which is expressed exclusively in cells of the lymphoid compartment, namely CD4+CD8+ double-positive thymoyctes, Th17 cells of the periphery and lymphoid tissue inducer (Lti) cells of lymphoid organs
  • The ROR gamma t isoform differs from ROR gamma by three unique amino acids at the amino terminus
  • Therefore, the B2D antibody will react with both the ROR gamma and ROR gamma t isoforms
  • Applications Reported: This B2D antibody has been reported for use in intracellular staining followed by flow cytometric analysis
  • Applications Tested: This B2D antibody has been tested by intracellular staining and flow cytometric analysis of mouse splenocytes using the Foxp3/Transcription Factor Staining Buffer Set (cat
  • 00-5523) and protocol
  • Please refer to Best Protocols: Protocol B: One step protocol for (nuclear) intracellular protein under the Resources Tab online
  • This can be used at less than or equal to 0.25 μg per test
  • ROR gamma, a NR1 Thyroid Hormone-Like receptor, has been shown to affect thymopoiesis, bone metabolism, T-cell apoptosis, and lymphoid organogenesis
  • ROR gamma has been shown to promote thymocyte survival by activating the expression of the antiapoptotic protein Bcl-x(L)
  • ROR gamma is also required for the development of lymph nodes and Peyer's patches
  • It has been shown that ROR gamma(t), a thymus-specific isoform of ROR gamma from mouse, inhibits Fas ligand expression and cytokine secretion in immature thymocytes
  • ROR gamma binds as a monomer to response elements composed of a single core motif, GGTCA, preceded by a 6 bp AT-rich sequence
  • ROR gamma expression has been documented in mouse thymus, adipose, bone, skeletal muscle, liver, and kidney, and in human skeletal muscle
  • ESTs have been isolated from human tissue libraries, including cancerous head/neck, germ cell, and prostate, and normal colon, head/neck, lung, liver/spleen, and pancreas
  • ROR gammat t (RORgt) is an isoform of RORC.

Compare Similar Items

Show Difference

Img

Fischer Scientific

50-112-4862

--


Antigen:
ROR gamma (t)

Classification:
Monoclonal

Concentration:
0.2 mg/mL

Formulation:
PBS with 0.09% sodium azide; pH 7.2

Gene Accession No.:
P51450

Gene Symbols:
Rorc

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
19885

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Form:
Liquid

Applications:
Flow Cytometry

Clone:
B2D

Conjugate:
PE-eFluor 610

Gene:
Rorc

Gene Alias:
EGK_01272; IMD42; MGC129539; NR1F3; nuclear receptor ROR-gamma; Nuclear receptor RZR-gamma; nuclear receptor subfamily 1 group F member 3; RAR related orphan receptor C; RAR-related orphan nuclear receptor variant 2; RAR-related orphan receptor C; RAR-related orphan receptor C, isoform a; RAR-related orphan receptor gamma; retinoic acid-binding receptor gamma; retinoid-related orphan receptor gamma; retinoid-related orphan receptor-gamma; ROR Gamma; ROR gamma t; Rorc; Rorg; RORgamma; RORgt; RP11-98D18.11-001; RZRG; RZR-GAMMA; Thor; Thymus orphan receptor; TOR

Host Species:
Rat

Quantity:
25 μg

Primary or Secondary:
Primary

Target Species:
Mouse

Product Type:
Antibody

Isotype:
IgG1 κ

Img

Fischer Scientific

50-112-4863

--


Antigen:
ROR gamma (t)

Classification:
Monoclonal

Concentration:
0.2 mg/mL

Formulation:
PBS with 0.09% sodium azide; pH 7.2

Gene Accession No.:
P51450

Gene Symbols:
Rorc

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
19885

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Form:
Liquid

Applications:
Flow Cytometry

Clone:
B2D

Conjugate:
PE-eFluor 610

Gene:
Rorc

Gene Alias:
EGK_01272; IMD42; MGC129539; NR1F3; nuclear receptor ROR-gamma; Nuclear receptor RZR-gamma; nuclear receptor subfamily 1 group F member 3; RAR related orphan receptor C; RAR-related orphan nuclear receptor variant 2; RAR-related orphan receptor C; RAR-related orphan receptor C, isoform a; RAR-related orphan receptor gamma; retinoic acid-binding receptor gamma; retinoid-related orphan receptor gamma; retinoid-related orphan receptor-gamma; ROR Gamma; ROR gamma t; Rorc; Rorg; RORgamma; RORgt; RP11-98D18.11-001; RZRG; RZR-GAMMA; Thor; Thymus orphan receptor; TOR

Host Species:
Rat

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Mouse

Product Type:
Antibody

Isotype:
IgG1 κ

Img

Fischer Scientific

50-112-4865

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Antigen:
IL-13

Classification:
Monoclonal

Concentration:
0.2 mg/mL

Formulation:
PBS with 0.09% sodium azide; pH 7.2

Gene Accession No.:
P20109

Gene Symbols:
Il13

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
16163

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Form:
Liquid

Applications:
Flow Cytometry

Clone:
eBio13A

Conjugate:
PE-eFluor 610

Gene:
Il13

Gene Alias:
ALRH; ALRH antibody; BHR1; il 13; Il13; Il-13; IL-13; cytokine; ILN; Interleukin; interleukin 13; Interleukin13; interleukin-13; interleukin-13 precursor; L13; MGC116786; MGC116788; MGC116789; NC30; NC30 antibody; P600; P600 antibody; T-cell activation protein P600

Host Species:
Rat

Quantity:
25 μg

Primary or Secondary:
Primary

Target Species:
Mouse

Product Type:
Antibody

Isotype:
IgG1 κ

Img

Invitrogen

50-112-4867

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Antigen:
IL-17A

Classification:
Monoclonal

Concentration:
0.2 mg/mL

Formulation:
PBS with 0.09% sodium azide; pH 7.2

Gene Accession No.:
Q61453, Q62386

Gene Symbols:
IL17A

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
16171, 301289

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Form:
Liquid

Applications:
Flow Cytometry

Clone:
eBio17B7

Conjugate:
PE-eFluor 610

Gene:
IL17A

Gene Alias:
Ctla8; CTLA-8; cytokine; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; il 17; Il17; IL-17; IL17A; IL-17a; ILN; Interleukin; interleukin 17; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17 precursor; interleukin 17A; interleukin-17; Interleukin17A; interleukin-17A; R-IL-17-A

Host Species:
Rat

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Mouse, Rat

Product Type:
Antibody

Isotype:
IgG2a κ