50-135-27
NFkB p50/p105 Polyclonal Antibody, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-135-27-Each-of-1 | In Stock | ₹ 13,604.04 |
50-135-27 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 13,604.04
GST (18%): ₹ 2,448.727
Total Price: ₹ 16,052.767
Antigen
NFkB p50/p105
Classification
Polyclonal
Conjugate
Unconjugated
Gene
NFKB1
Gene Alias
CVID12; DKFZp686C01211; DNA-binding factor KBF1; EBP-1; KBF1; MGC54151; NF kappaB1; NF KB; NFkappaB; NF-kappaB; NF-kappa-B; NF-kappaB p50; NF-kappaB1; NF-kappa-B1 p84/NF-kappa-B1 p98; NF-kappabeta; NF-kB; NFKB1; NF-KB1; NFKB-p105; NFKB-p50; nuclear factor; nuclear factor kappa b; nuclear factor kappa B subunit 1; nuclear factor kappa-B DNA binding subunit; nuclear factor kappaB p50; nuclear factor NF-kappa-B p105 subunit; Nuclear factor NF-kappa-B p50 subunit; nuclear factor of kappa light chain gene enhancer in B-cells 1, p105; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105; nuclear factor-kappaB p50; p105; p50; p50 subunit of NF kappaB; p50 subunit of NF-kappaB; p50/p105
Host Species
Rabbit
Quantity
50 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry, Immunoprecipitation, Western Blot
Concentration
0.2 mg/mL
Formulation
PBS with 0.02% gelatin, BSA and 0.1% sodium azide
Gene Accession No.
P19838, P25799, Q63369
Gene Symbols
NFKB1
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
18033, 4790, 81736
Content And Storage
4° C
Form
Liquid
Description
- Description: The polyclonal antibody reacts with mouse, rat, and human NFkB p50; the antibody was raised against a peptide mapping to the carboxy terminus of human NFkB p50
- Members of the rel/NFkB family of transcription factors are involved in the regulation of cellular responses, such as growth, development, and the inflammatory response
- They share a structural motif known as the rel homology region (RHR), the C-terminal one third of which mediates protein dimerization (2, 6, 8)
- Complexes of p50 (NF-kB1) or p52 (NF-kB2) are generated through the processing of p105 and p100 precursors, respectively
- These are usually associated with members of the Rel family (p65, c-Rel, Rel B)
- The homo- and heterodimer formed through combinations of NFkB/Rel proteins bind distinct kB sites to regulate the transcription of different genes (7, 9)
- In resting cells, NFkB is retained in the cytoplasm bound to inhibitory proteins of the IkB family
- Degradation of IkB proteins occurs with cell activation, via of variety of signals, including inflammatory cytokines and bacterial lipopolysaccharides (LPS) as well as oxidative and fluid mechanical stress
- This results in nuclear translocation of NFkB and the transcriptional gene activation of proinflammatory genes (1, 9)
- It has been suggested that NFkB plays a role in the development of numerous pathological states
- NF-kB is a nuclear transcription factor activated by various extra and intracellular stimuli such as cytokines, UV radiation, stress, in injury, and by bacterial and viral products
- It is involved in regulation of various cellular events including cell growth, differentiation, proliferation, apoptosis and inflammation
- NFKB1 (p50), a 50KDa functional sub-unit of NF-kB, is a member of Rel protein family
- It is synthesized as a p105 precursor protein and consists of an N-terminal conserved RHD-region containing nuclear localization signal, DNA-binding and dimerization domains
- NFKB1 (p50) forms homodimers or heterodimerizes with p65, forming the functional NF-kB factor
- NFKB1 (p50) directs the nuclear translocation of NF-kB and is instrumental in its DNA-bidning
- Pathological role of NF-kB has been suggested in AIDS, hematogenic cancer cell metastasis and rheumatoid arthritis.
Compare Similar Items
Show Difference
Antigen: NFkB p50/p105
Classification: Polyclonal
Conjugate: Unconjugated
Gene: NFKB1
Gene Alias: CVID12; DKFZp686C01211; DNA-binding factor KBF1; EBP-1; KBF1; MGC54151; NF kappaB1; NF KB; NFkappaB; NF-kappaB; NF-kappa-B; NF-kappaB p50; NF-kappaB1; NF-kappa-B1 p84/NF-kappa-B1 p98; NF-kappabeta; NF-kB; NFKB1; NF-KB1; NFKB-p105; NFKB-p50; nuclear factor; nuclear factor kappa b; nuclear factor kappa B subunit 1; nuclear factor kappa-B DNA binding subunit; nuclear factor kappaB p50; nuclear factor NF-kappa-B p105 subunit; Nuclear factor NF-kappa-B p50 subunit; nuclear factor of kappa light chain gene enhancer in B-cells 1, p105; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105; nuclear factor-kappaB p50; p105; p50; p50 subunit of NF kappaB; p50 subunit of NF-kappaB; p50/p105
Host Species: Rabbit
Quantity: 50 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Concentration: 0.2 mg/mL
Formulation: PBS with 0.02% gelatin, BSA and 0.1% sodium azide
Gene Accession No.: P19838, P25799, Q63369
Gene Symbols: NFKB1
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 18033, 4790, 81736
Content And Storage: 4° C
Form: Liquid
Antigen:
NFkB p50/p105
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
NFKB1
Gene Alias:
CVID12; DKFZp686C01211; DNA-binding factor KBF1; EBP-1; KBF1; MGC54151; NF kappaB1; NF KB; NFkappaB; NF-kappaB; NF-kappa-B; NF-kappaB p50; NF-kappaB1; NF-kappa-B1 p84/NF-kappa-B1 p98; NF-kappabeta; NF-kB; NFKB1; NF-KB1; NFKB-p105; NFKB-p50; nuclear factor; nuclear factor kappa b; nuclear factor kappa B subunit 1; nuclear factor kappa-B DNA binding subunit; nuclear factor kappaB p50; nuclear factor NF-kappa-B p105 subunit; Nuclear factor NF-kappa-B p50 subunit; nuclear factor of kappa light chain gene enhancer in B-cells 1, p105; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105; nuclear factor-kappaB p50; p105; p50; p50 subunit of NF kappaB; p50 subunit of NF-kappaB; p50/p105
Host Species:
Rabbit
Quantity:
50 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunohistochemistry, Immunoprecipitation, Western Blot
Concentration:
0.2 mg/mL
Formulation:
PBS with 0.02% gelatin, BSA and 0.1% sodium azide
Gene Accession No.:
P19838, P25799, Q63369
Gene Symbols:
NFKB1
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
18033, 4790, 81736
Content And Storage:
4° C
Form:
Liquid
Antigen: beta Galactosidase Fusion Protein
Classification: Polyclonal
Conjugate: Unconjugated
Gene: __
Gene Alias: acid beta-galactosidase; AW125515; betagal; Beta-Gal; Beta-galactosidase; bgal; Bge; Bgl; Bgl-e; Bgl-s; Bgl-t; Bgs; Bgt; C130097A14Rik; EBP; Elastin receptor 1; elastin receptor 1, 67kDa; ELNR1; galactosidase beta 1; galactosidase, beta 1; GLB1; Glb-1; lactase; lysosmal hydrolase; lysosomal beta-galactosidase; lysosomal hydrolase; MPS4B; βgal; β-gal; β-galactosidase
Host Species: Rabbit
Quantity: 50 μg
Primary or Secondary: Primary
Target Species: Bacteria
Product Type: Antibody
Isotype: IgG
Applications: Immunohistochemistry, Western Blot
Concentration: 0.2 mg/mL
Formulation: PBS with 0.02% gelatin, BSA and 0.1% sodium azide
Gene Accession No.: __
Gene Symbols: __
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): __
Content And Storage: 4° C
Form: Liquid
Antigen:
beta Galactosidase Fusion Protein
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
__
Gene Alias:
acid beta-galactosidase; AW125515; betagal; Beta-Gal; Beta-galactosidase; bgal; Bge; Bgl; Bgl-e; Bgl-s; Bgl-t; Bgs; Bgt; C130097A14Rik; EBP; Elastin receptor 1; elastin receptor 1, 67kDa; ELNR1; galactosidase beta 1; galactosidase, beta 1; GLB1; Glb-1; lactase; lysosmal hydrolase; lysosomal beta-galactosidase; lysosomal hydrolase; MPS4B; βgal; β-gal; β-galactosidase
Host Species:
Rabbit
Quantity:
50 μg
Primary or Secondary:
Primary
Target Species:
Bacteria
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunohistochemistry, Western Blot
Concentration:
0.2 mg/mL
Formulation:
PBS with 0.02% gelatin, BSA and 0.1% sodium azide
Gene Accession No.:
__
Gene Symbols:
__
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
__
Content And Storage:
4° C
Form:
Liquid
Antigen: __
Classification: __
Conjugate: __
Gene: __
Gene Alias: __
Host Species: __
Quantity: __
Primary or Secondary: __
Target Species: __
Product Type: __
Isotype: __
Applications: __
Concentration: __
Formulation: __
Gene Accession No.: __
Gene Symbols: __
Purification Method: __
Regulatory Status: __
Gene ID (Entrez): __
Content And Storage: __
Form: __
Antigen:
__
Classification:
__
Conjugate:
__
Gene:
__
Gene Alias:
__
Host Species:
__
Quantity:
__
Primary or Secondary:
__
Target Species:
__
Product Type:
__
Isotype:
__
Applications:
__
Concentration:
__
Formulation:
__
Gene Accession No.:
__
Gene Symbols:
__
Purification Method:
__
Regulatory Status:
__
Gene ID (Entrez):
__
Content And Storage:
__
Form:
__
Antigen: __
Classification: __
Conjugate: __
Gene: __
Gene Alias: __
Host Species: __
Quantity: __
Primary or Secondary: __
Target Species: __
Product Type: __
Isotype: __
Applications: __
Concentration: __
Formulation: __
Gene Accession No.: __
Gene Symbols: __
Purification Method: __
Regulatory Status: __
Gene ID (Entrez): __
Content And Storage: __
Form: __
Antigen:
__
Classification:
__
Conjugate:
__
Gene:
__
Gene Alias:
__
Host Species:
__
Quantity:
__
Primary or Secondary:
__
Target Species:
__
Product Type:
__
Isotype:
__
Applications:
__
Concentration:
__
Formulation:
__
Gene Accession No.:
__
Gene Symbols:
__
Purification Method:
__
Regulatory Status:
__
Gene ID (Entrez):
__
Content And Storage:
__
Form:
__