CCAR1 Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
• Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter
• Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone
• Also functions as a p53 coactivator
• May thus play an important role in transcriptional regulation
• May be involved in apoptosis signaling in the presence of the reinoid CD437
• Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A
• Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952)
• In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781)
• Can act as a both a coactivator and corepressor of AR-mediated transcription
• Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites
• May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938).