PPP1CC Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Application Note: For IHC, epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections
• Based on 100% sequence identity, this antibody is predicted to Protein phosphatase-1 (PP1) is one of the major Ser/Thr protein phosphatases and is ubiquitous in eukaryotic cells
• PP1 is localized to its site of action by interacting with targeting or regulatory proteins, a majority of which contains a primary docking site referred to as the RVXF/W motif
• The catalytic subunit of PP1 exists as three isoforms, PP1a, PP1b, and PP1r
• The PP1 catalytic subunits are small proteins of 37kDa, which are highly conserved, with their main differences falling in the C-term
• The PP1 catalytic subunit exists in the cell in complex with a large number of targeting/regulatory subunits, thereby generating different enzyme forms that allow it to perform a diverse number of cellular functions.