50-157-2190
DTL/CDT2 Polyclonal Antibody, Bethyl Laboratories
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-157-2190-Each-of-1 | In Stock | ₹ 11,905.67 |
50-157-2190 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 11,905.67
GST (18%): ₹ 2,143.021
Total Price: ₹ 14,048.691
Antigen
DTL/CDT2
Classification
Polyclonal
Formulation
TBS with 0.1% BSA and 0.09% sodium azide
Gene Accession No.
Q3TLR7, Q9NZJ0
Gene Symbols
Dtl
Immunogen
Between 680 and C-term
Quantity
10 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry
Conjugate
Unconjugated
Gene
DTL
Gene Alias
CDT2, DCAF2, L2DTL, RAMP, DDB1 and CUL4 associated factor 2, DDB1- and CUL4-associated factor 2, RA regulated nuclear matrix associated protein, RA-regulated nuclear matrix-associated protein, denticleless protein homolog, lethal(2) denticleless protein homolog, retinoic acid-regulated
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
51514, 76843
Content And Storage
4° C
Form
Liquid
Related Products
Description
- The recommended shelf life for this product is 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Monkey, Gorilla, Chimpanzee, Northern white-cheeked gibbon and Crab-eating macaque Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis
- The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1)
- CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication
- CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing
- Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation
- In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.
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Antigen: DTL/CDT2
Classification: Polyclonal
Formulation: TBS with 0.1% BSA and 0.09% sodium azide
Gene Accession No.: Q3TLR7, Q9NZJ0
Gene Symbols: Dtl
Immunogen: Between 680 and C-term
Quantity: 10 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Applications: Immunohistochemistry
Conjugate: Unconjugated
Gene: DTL
Gene Alias: CDT2, DCAF2, L2DTL, RAMP, DDB1 and CUL4 associated factor 2, DDB1- and CUL4-associated factor 2, RA regulated nuclear matrix associated protein, RA-regulated nuclear matrix-associated protein, denticleless protein homolog, lethal(2) denticleless protein homolog, retinoic acid-regulated
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 51514, 76843
Content And Storage: 4° C
Form: Liquid
Antigen:
DTL/CDT2
Classification:
Polyclonal
Formulation:
TBS with 0.1% BSA and 0.09% sodium azide
Gene Accession No.:
Q3TLR7, Q9NZJ0
Gene Symbols:
Dtl
Immunogen:
Between 680 and C-term
Quantity:
10 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunohistochemistry
Conjugate:
Unconjugated
Gene:
DTL
Gene Alias:
CDT2, DCAF2, L2DTL, RAMP, DDB1 and CUL4 associated factor 2, DDB1- and CUL4-associated factor 2, RA regulated nuclear matrix associated protein, RA-regulated nuclear matrix-associated protein, denticleless protein homolog, lethal(2) denticleless protein homolog, retinoic acid-regulated
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
51514, 76843
Content And Storage:
4° C
Form:
Liquid
Antigen: BubR1
Classification: Polyclonal
Formulation: TBS with 0.1% BSA and 0.09% sodium azide
Gene Accession No.: O60566
Gene Symbols: BUB1B
Immunogen: Between 1 and 50
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Immunohistochemistry
Conjugate: Unconjugated
Gene: BUB1B
Gene Alias: BUB1B, Budding Uninhibited by Benzimidazoles 1 beta, hBUBR1, MAD3L
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 701
Content And Storage: 4° C
Form: Liquid
Antigen:
BubR1
Classification:
Polyclonal
Formulation:
TBS with 0.1% BSA and 0.09% sodium azide
Gene Accession No.:
O60566
Gene Symbols:
BUB1B
Immunogen:
Between 1 and 50
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunohistochemistry
Conjugate:
Unconjugated
Gene:
BUB1B
Gene Alias:
BUB1B, Budding Uninhibited by Benzimidazoles 1 beta, hBUBR1, MAD3L
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
701
Content And Storage:
4° C
Form:
Liquid
Antigen: BubR1
Classification: Polyclonal
Formulation: TBS with 0.1% BSA and 0.09% sodium azide
Gene Accession No.: O60566
Gene Symbols: BUB1B
Immunogen: Between 1 and 50
Quantity: 10 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Immunohistochemistry
Conjugate: Unconjugated
Gene: BUB1B
Gene Alias: BUB1B, Budding Uninhibited by Benzimidazoles 1 beta, hBUBR1, MAD3L
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 701
Content And Storage: 4° C
Form: Liquid
Antigen:
BubR1
Classification:
Polyclonal
Formulation:
TBS with 0.1% BSA and 0.09% sodium azide
Gene Accession No.:
O60566
Gene Symbols:
BUB1B
Immunogen:
Between 1 and 50
Quantity:
10 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunohistochemistry
Conjugate:
Unconjugated
Gene:
BUB1B
Gene Alias:
BUB1B, Budding Uninhibited by Benzimidazoles 1 beta, hBUBR1, MAD3L
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
701
Content And Storage:
4° C
Form:
Liquid
Antigen: CASC5
Classification: Polyclonal
Formulation: TBS with 0.1% BSA and 0.09% sodium azide
Gene Accession No.: Q8NG31
Gene Symbols: KNL1
Immunogen: Between 300 and 350
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Immunohistochemistry
Conjugate: Unconjugated
Gene: KNL1
Gene Alias: Protein CASC5, Cancer susceptibility candidate gene 5 protein homolog, Kinetochore-null protein 1, Casc5, Knl1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 57082
Content And Storage: 4° C
Form: Liquid
Antigen:
CASC5
Classification:
Polyclonal
Formulation:
TBS with 0.1% BSA and 0.09% sodium azide
Gene Accession No.:
Q8NG31
Gene Symbols:
KNL1
Immunogen:
Between 300 and 350
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunohistochemistry
Conjugate:
Unconjugated
Gene:
KNL1
Gene Alias:
Protein CASC5, Cancer susceptibility candidate gene 5 protein homolog, Kinetochore-null protein 1, Casc5, Knl1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
57082
Content And Storage:
4° C
Form:
Liquid