BMP-4 Monoclonal Antibody, PeproTech®, Invitrogen™

Description

• AA Sequence of recombinant protein: HHSQRARKKN KNCRRHSLYV DFSDVGWNDW IVAPPGYQAF YCHGDCPFPL ADHLNSTNHA IVQTLVNSVN SSIPKACCVP TELSAISMLY LDEYDKVVLK NYQEMVVEGC GCR
• Preparation: Produced in mice immunized with highly pure Recombinant Human BMP-4
• Anti-Human BMP-4-specific antibody was purified from cell culture by Protein G affinity chromatography
• The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily
• The superfamily includes large families of growth and differentiation factors
• Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site
• This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva
• Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.