50-166-7125
SAV1 Mouse anti-Human, Clone: OTI2B7, lyophilized, TrueMAB™
Manufacturer: OriGene
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-166-7125-Each-of-1 | In Stock | ₹ 60,342.00 |
50-166-7125 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 60,342.00
GST (18%): ₹ 10,861.56
Total Price: ₹ 71,203.56
Antigen
SAV1
Classification
Monoclonal
Conjugate
Unconjugated
Gene
SAV1
Gene Alias
SAV, WW45, WWP4
Host Species
Mouse
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
60485
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Lyophilized
Applications
Western Blot
Clone
OTI2B7
Formulation
PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.
Q9H4B6
Gene Symbols
SAV1
Immunogen
Human recombit protein fragment corresponding to amino acids 167-383 of human SAV1 produced in E.coli.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Related Products
Description
- Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No
- 7KMWCO Sav1 is a regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis
- The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ
- Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration
- SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues
- It also plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250
- In conjunction with STK3/MST2, Sav1 activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.
Compare Similar Items
Show Difference
Antigen: SAV1
Classification: Monoclonal
Conjugate: Unconjugated
Gene: SAV1
Gene Alias: SAV, WW45, WWP4
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 60485
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Lyophilized
Applications: Western Blot
Clone: OTI2B7
Formulation: PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.: Q9H4B6
Gene Symbols: SAV1
Immunogen: Human recombit protein fragment corresponding to amino acids 167-383 of human SAV1 produced in E.coli.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Antigen:
SAV1
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene:
SAV1
Gene Alias:
SAV, WW45, WWP4
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
60485
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Lyophilized
Applications:
Western Blot
Clone:
OTI2B7
Formulation:
PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.:
Q9H4B6
Gene Symbols:
SAV1
Immunogen:
Human recombit protein fragment corresponding to amino acids 167-383 of human SAV1 produced in E.coli.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Antigen: MEOX1
Classification: Monoclonal
Conjugate: Unconjugated
Gene: MEOX1
Gene Alias: KFS2, MOX1
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 4222
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Lyophilized
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: OTI2F4
Formulation: PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.: P50221
Gene Symbols: MEOX1
Immunogen: Full length human recombit protein of human MEOX1 produced in E.coli.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Antigen:
MEOX1
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene:
MEOX1
Gene Alias:
KFS2, MOX1
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
4222
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Lyophilized
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
OTI2F4
Formulation:
PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.:
P50221
Gene Symbols:
MEOX1
Immunogen:
Full length human recombit protein of human MEOX1 produced in E.coli.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Antigen: RSPO1
Classification: Monoclonal
Conjugate: Unconjugated
Gene: RSPO1
Gene Alias: CRISTIN3, RSPO
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 284654
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Lyophilized
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: OTI1C3
Formulation: PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.: Q2MKA7
Gene Symbols: RSPO1
Immunogen: Human recombit protein fragment corresponding to amino acids 21-263 of human RSPO1 produced in E.coli.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Antigen:
RSPO1
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene:
RSPO1
Gene Alias:
CRISTIN3, RSPO
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
284654
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Lyophilized
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
OTI1C3
Formulation:
PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.:
Q2MKA7
Gene Symbols:
RSPO1
Immunogen:
Human recombit protein fragment corresponding to amino acids 21-263 of human RSPO1 produced in E.coli.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Antigen: XRCC3
Classification: Monoclonal
Conjugate: Unconjugated
Gene: XRCC3
Gene Alias: CMM6
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 7517
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Lyophilized
Applications: Western Blot
Clone: OTI1C1
Formulation: PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.: O43542
Gene Symbols: XRCC3
Immunogen: Human recombit protein fragment corresponding to amino acids 1-235 of human XRCC3 produced in E.coli.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Antigen:
XRCC3
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene:
XRCC3
Gene Alias:
CMM6
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
7517
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Lyophilized
Applications:
Western Blot
Clone:
OTI1C1
Formulation:
PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.:
O43542
Gene Symbols:
XRCC3
Immunogen:
Human recombit protein fragment corresponding to amino acids 1-235 of human XRCC3 produced in E.coli.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1