50-166-7218
SAV1 Mouse anti-Human, Clone: OTI7C7, lyophilized, TrueMAB™
Manufacturer: OriGene
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-166-7218-Each-of-1 | In Stock | ₹ 58,009.68 |
50-166-7218 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 58,009.68
GST (18%): ₹ 10,441.742
Total Price: ₹ 68,451.422
Antigen
SAV1
Classification
Monoclonal
Conjugate
Unconjugated
Gene
SAV1
Gene Alias
SAV, WW45, WWP4
Host Species
Mouse
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
60485
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Lyophilized
Applications
Western Blot
Clone
OTI7C7
Formulation
PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.
Q9H4B6
Gene Symbols
SAV1
Immunogen
Human recombit protein fragment corresponding to amino acids 167-383 of human SAV1 produced in E.coli.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Related Products
Description
- Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No
- 7KMWCO Sav1 is a regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis
- The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ
- Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration
- SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues
- It also plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250
- In conjunction with STK3/MST2, Sav1 activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.
Compare Similar Items
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Antigen: SAV1
Classification: Monoclonal
Conjugate: Unconjugated
Gene: SAV1
Gene Alias: SAV, WW45, WWP4
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 60485
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Lyophilized
Applications: Western Blot
Clone: OTI7C7
Formulation: PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.: Q9H4B6
Gene Symbols: SAV1
Immunogen: Human recombit protein fragment corresponding to amino acids 167-383 of human SAV1 produced in E.coli.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Antigen:
SAV1
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene:
SAV1
Gene Alias:
SAV, WW45, WWP4
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
60485
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Lyophilized
Applications:
Western Blot
Clone:
OTI7C7
Formulation:
PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.:
Q9H4B6
Gene Symbols:
SAV1
Immunogen:
Human recombit protein fragment corresponding to amino acids 167-383 of human SAV1 produced in E.coli.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Antigen: GATAD1
Classification: Monoclonal
Conjugate: Unconjugated
Gene: GATAD1
Gene Alias: CMD2B, ODAG, RG083M05.2
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 57798
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Lyophilized
Applications: Western Blot
Clone: OTI1F10
Formulation: PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.: Q8WUU5
Gene Symbols: GATAD1
Immunogen: Human recombit protein fragment corresponding to amino acids 68-269 of human GATAD1 produced in E.coli.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Antigen:
GATAD1
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene:
GATAD1
Gene Alias:
CMD2B, ODAG, RG083M05.2
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
57798
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Lyophilized
Applications:
Western Blot
Clone:
OTI1F10
Formulation:
PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.:
Q8WUU5
Gene Symbols:
GATAD1
Immunogen:
Human recombit protein fragment corresponding to amino acids 68-269 of human GATAD1 produced in E.coli.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Antigen: PCNA
Classification: Monoclonal
Conjugate: Unconjugated
Gene: PCNA
Gene Alias: ATLD2
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 5111
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Lyophilized
Applications: Western Blot
Clone: OTI11F12
Formulation: PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.: P12004
Gene Symbols: PCNA
Immunogen: Full length human recombit protein of human PCNA produced in E.coli.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG2a
Antigen:
PCNA
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene:
PCNA
Gene Alias:
ATLD2
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
5111
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Lyophilized
Applications:
Western Blot
Clone:
OTI11F12
Formulation:
PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.:
P12004
Gene Symbols:
PCNA
Immunogen:
Full length human recombit protein of human PCNA produced in E.coli.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG2a
Antigen: PARP1
Classification: Monoclonal
Conjugate: Unconjugated
Gene: PARP1
Gene Alias: ADPRT, ADPRT 1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 142
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Lyophilized
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: OTI5F1
Formulation: PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.: P09874
Gene Symbols: PARP1
Immunogen: Full length human recombit protein of human PARP1 produced in E.coli.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Antigen:
PARP1
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene:
PARP1
Gene Alias:
ADPRT, ADPRT 1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
142
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Lyophilized
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
OTI5F1
Formulation:
PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.:
P09874
Gene Symbols:
PARP1
Immunogen:
Full length human recombit protein of human PARP1 produced in E.coli.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1