50-166-7218
SAV1 Mouse anti-Human, Clone: OTI7C7, lyophilized, TrueMAB™
Manufacturer: OriGene
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-166-7218-Each-of-1 | In Stock | ₹ 60,342.00 |
50-166-7218 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 60,342.00
GST (18%): ₹ 10,861.56
Total Price: ₹ 71,203.56
Antigen
SAV1
Classification
Monoclonal
Conjugate
Unconjugated
Gene
SAV1
Gene Alias
SAV, WW45, WWP4
Host Species
Mouse
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
60485
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Lyophilized
Applications
Western Blot
Clone
OTI7C7
Formulation
PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.
Q9H4B6
Gene Symbols
SAV1
Immunogen
Human recombit protein fragment corresponding to amino acids 167-383 of human SAV1 produced in E.coli.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Related Products
Description
- Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No
- 7KMWCO Sav1 is a regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis
- The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ
- Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration
- SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues
- It also plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250
- In conjunction with STK3/MST2, Sav1 activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.
Compare Similar Items
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Antigen: SAV1
Classification: Monoclonal
Conjugate: Unconjugated
Gene: SAV1
Gene Alias: SAV, WW45, WWP4
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 60485
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Lyophilized
Applications: Western Blot
Clone: OTI7C7
Formulation: PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.: Q9H4B6
Gene Symbols: SAV1
Immunogen: Human recombit protein fragment corresponding to amino acids 167-383 of human SAV1 produced in E.coli.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Antigen:
SAV1
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene:
SAV1
Gene Alias:
SAV, WW45, WWP4
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
60485
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Lyophilized
Applications:
Western Blot
Clone:
OTI7C7
Formulation:
PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.:
Q9H4B6
Gene Symbols:
SAV1
Immunogen:
Human recombit protein fragment corresponding to amino acids 167-383 of human SAV1 produced in E.coli.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Antigen: GATAD1
Classification: Monoclonal
Conjugate: Unconjugated
Gene: GATAD1
Gene Alias: CMD2B, ODAG, RG083M05.2
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 57798
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Lyophilized
Applications: Western Blot
Clone: OTI1F10
Formulation: PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.: Q8WUU5
Gene Symbols: GATAD1
Immunogen: Human recombit protein fragment corresponding to amino acids 68-269 of human GATAD1 produced in E.coli.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Antigen:
GATAD1
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene:
GATAD1
Gene Alias:
CMD2B, ODAG, RG083M05.2
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
57798
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Lyophilized
Applications:
Western Blot
Clone:
OTI1F10
Formulation:
PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.:
Q8WUU5
Gene Symbols:
GATAD1
Immunogen:
Human recombit protein fragment corresponding to amino acids 68-269 of human GATAD1 produced in E.coli.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Antigen: PCNA
Classification: Monoclonal
Conjugate: Unconjugated
Gene: PCNA
Gene Alias: ATLD2
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 5111
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Lyophilized
Applications: Western Blot
Clone: OTI11F12
Formulation: PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.: P12004
Gene Symbols: PCNA
Immunogen: Full length human recombit protein of human PCNA produced in E.coli.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG2a
Antigen:
PCNA
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene:
PCNA
Gene Alias:
ATLD2
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
5111
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Lyophilized
Applications:
Western Blot
Clone:
OTI11F12
Formulation:
PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.:
P12004
Gene Symbols:
PCNA
Immunogen:
Full length human recombit protein of human PCNA produced in E.coli.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG2a
Antigen: PARP1
Classification: Monoclonal
Conjugate: Unconjugated
Gene: PARP1
Gene Alias: ADPRT, ADPRT 1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 142
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Lyophilized
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: OTI5F1
Formulation: PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.: P09874
Gene Symbols: PARP1
Immunogen: Full length human recombit protein of human PARP1 produced in E.coli.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Antigen:
PARP1
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene:
PARP1
Gene Alias:
ADPRT, ADPRT 1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
142
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Lyophilized
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
OTI5F1
Formulation:
PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.:
P09874
Gene Symbols:
PARP1
Immunogen:
Full length human recombit protein of human PARP1 produced in E.coli.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1