50-167-1369
DFF45 Mouse anti-Human, Clone: OTI1B10, liquid, TrueMAB™
Manufacturer: OriGene
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-167-1369-Each-of-1 | In Stock | ₹ 43,217.21 |
50-167-1369 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 43,217.21
GST (18%): ₹ 7,779.098
Total Price: ₹ 50,996.308
Antigen
DFF45
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.
O00273
Gene Symbols
DFFA
Immunogen
Recombit protein expressed in E.coli corresponding to amino acids 1-331 of human DFF45
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Immunocytochemistry, Immunofluorescence, Western Blot
Clone
OTI1B10
Conjugate
Unconjugated
Gene
DFFA
Gene Alias
DFF-45, DFF1, ICAD
Host Species
Mouse
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
1676
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- ICAD is the inhibitor of caspase-3-activated DNase which is a substrate that controls nuclear apoptosis
- ICAD has two isoforms: a functional isoform of 45kDa, ICAD-L/DNA fragmentation factor (DFF) 45; and a 35kDa isoform, ICAD-S/DFF35
- Although both ICAD-L and ICAD-S can bind and inhibit CAD, only ICAD-L was reported to be functional
- ICAD is cleaved to be inactivated and allow caspase-activated DNase (CAD) to execute nuclear internucleosomal apoptotic DNA fragmentation
- In non-apoptotic cells, CAD is complexed with its inhibitor, ICAD
- The activation of the CAD/ICAD complex occurs through the caspase 3-mediated cleavage of ICAD at residues 117 and 224, which results in three ICAD fragments that are then released from CAD
- In addition to its DNase inhibitory activity, ICAD acts as a CAD specific folding chaperone
- There are recent reports that ICAD is a potential target for restoring a normal apoptotic signal transduction pathway in colon and brain cancer cells
- Two alternatively spliced transcript variants encoding distinct isoforms have been found for the ICAD gene.
Compare Similar Items
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Antigen: DFF45
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.: O00273
Gene Symbols: DFFA
Immunogen: Recombit protein expressed in E.coli corresponding to amino acids 1-331 of human DFF45
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Applications: Immunocytochemistry, Immunofluorescence, Western Blot
Clone: OTI1B10
Conjugate: Unconjugated
Gene: DFFA
Gene Alias: DFF-45, DFF1, ICAD
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 1676
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
DFF45
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.:
O00273
Gene Symbols:
DFFA
Immunogen:
Recombit protein expressed in E.coli corresponding to amino acids 1-331 of human DFF45
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
Immunocytochemistry, Immunofluorescence, Western Blot
Clone:
OTI1B10
Conjugate:
Unconjugated
Gene:
DFFA
Gene Alias:
DFF-45, DFF1, ICAD
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
1676
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: __
Classification: __
Concentration: __
Formulation: __
Gene Accession No.: __
Gene Symbols: __
Immunogen: __
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Target Species: __
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Isotype: __
Applications: __
Clone: __
Conjugate: __
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Purification Method: __
Regulatory Status: __
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Content And Storage: __
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Antigen:
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Classification:
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Concentration:
__
Formulation:
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Gene Accession No.:
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Gene Symbols:
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Immunogen:
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Quantity:
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Primary or Secondary:
__
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Isotype:
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Clone:
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Conjugate:
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Antigen: DFF45
Classification: Monoclonal
Concentration: 0.2 mg/mL
Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.: O00273
Gene Symbols: DFFA
Immunogen: Full length human recombit protein of human DFFA produced in E.coli.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Applications: Immunocytochemistry, Immunofluorescence, Western Blot
Clone: OTI5C4
Conjugate: Unconjugated
Gene: DFFA
Gene Alias: DFF-45, DFF1, ICAD
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 1676
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
DFF45
Classification:
Monoclonal
Concentration:
0.2 mg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.:
O00273
Gene Symbols:
DFFA
Immunogen:
Full length human recombit protein of human DFFA produced in E.coli.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
Immunocytochemistry, Immunofluorescence, Western Blot
Clone:
OTI5C4
Conjugate:
Unconjugated
Gene:
DFFA
Gene Alias:
DFF-45, DFF1, ICAD
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
1676
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: DFF45
Classification: Monoclonal
Concentration: 0.2 mg/mL
Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.: O00273
Gene Symbols: DFFA
Immunogen: Full length human recombit protein of human DFFA produced in E.coli.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Applications: Immunocytochemistry, Immunofluorescence, Western Blot
Clone: OTI3F12
Conjugate: Unconjugated
Gene: DFFA
Gene Alias: DFF-45, DFF1, ICAD
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 1676
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
DFF45
Classification:
Monoclonal
Concentration:
0.2 mg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.:
O00273
Gene Symbols:
DFFA
Immunogen:
Full length human recombit protein of human DFFA produced in E.coli.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
Immunocytochemistry, Immunofluorescence, Western Blot
Clone:
OTI3F12
Conjugate:
Unconjugated
Gene:
DFFA
Gene Alias:
DFF-45, DFF1, ICAD
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
1676
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid