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50-167-1371

DFF45 Mouse anti-Human, Clone: OTI3F12, liquid, TrueMAB™

Manufacturer: OriGene

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Pack Size SKU Availability Price
Each of 1 50-167-1371-Each-of-1 In Stock ₹ 43,217.21

50-167-1371 - Each of 1

₹ 43,217.21

In Stock

Quantity

1

Base Price: ₹ 43,217.21

GST (18%): ₹ 7,779.098

Total Price: ₹ 50,996.308

Antigen

DFF45

Classification

Monoclonal

Concentration

0.2 mg/mL

Formulation

PBS with 1% BSA, 50% glycerol and 0.02% sodium azide

Gene Accession No.

O00273

Gene Symbols

DFFA

Immunogen

Full length human recombit protein of human DFFA produced in E.coli.

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG1

Applications

Immunocytochemistry, Immunofluorescence, Western Blot

Clone

OTI3F12

Conjugate

Unconjugated

Gene

DFFA

Gene Alias

DFF-45, DFF1, ICAD

Host Species

Mouse

Purification Method

Affinity Chromatography

Regulatory Status

RUO

Gene ID (Entrez)

1676

Content And Storage

-20° C, Avoid Freeze/Thaw Cycles

Form

Liquid

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Description

  • ICAD is the inhibitor of caspase-3-activated DNase which is a substrate that controls nuclear apoptosis
  • ICAD has two isoforms: a functional isoform of 45kDa, ICAD-L/DNA fragmentation factor (DFF) 45; and a 35kDa isoform, ICAD-S/DFF35
  • Although both ICAD-L and ICAD-S can bind and inhibit CAD, only ICAD-L was reported to be functional
  • ICAD is cleaved to be inactivated and allow caspase-activated DNase (CAD) to execute nuclear internucleosomal apoptotic DNA fragmentation
  • In non-apoptotic cells, CAD is complexed with its inhibitor, ICAD
  • The activation of the CAD/ICAD complex occurs through the caspase 3-mediated cleavage of ICAD at residues 117 and 224, which results in three ICAD fragments that are then released from CAD
  • In addition to its DNase inhibitory activity, ICAD acts as a CAD specific folding chaperone
  • There are recent reports that ICAD is a potential target for restoring a normal apoptotic signal transduction pathway in colon and brain cancer cells
  • Two alternatively spliced transcript variants encoding distinct isoforms have been found for the ICAD gene.

Compare Similar Items

Show Difference

Img

OriGene

50-167-1371

--

Antigen:
DFF45
Classification:
Monoclonal
Concentration:
0.2 mg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.:
O00273
Gene Symbols:
DFFA
Immunogen:
Full length human recombit protein of human DFFA produced in E.coli.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
Immunocytochemistry, Immunofluorescence, Western Blot
Clone:
OTI3F12
Conjugate:
Unconjugated
Gene:
DFFA
Gene Alias:
DFF-45, DFF1, ICAD
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
1676
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid

Img

OriGene

50-167-1372

--

Antigen:
aFGF
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.:
P05230
Gene Symbols:
FGF1
Immunogen:
Human recombit protein fragment corresponding to amino acids 16-155 of human AFGF produced in E.coli.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
Immunocytochemistry, Immunofluorescence, Western Blot
Clone:
OTI4D2
Conjugate:
Unconjugated
Gene:
FGF1
Gene Alias:
AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
2246
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid

Img

OriGene

50-167-1375

--

Antigen:
IL6
Classification:
Monoclonal
Concentration:
__
Formulation:
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.:
P05231
Gene Symbols:
IL6
Immunogen:
Human recombit protein fragment corresponding to amino acids 29-212 of human IL-6 produced in E.coli.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG2a
Applications:
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Clone:
OTI3G9
Conjugate:
Unconjugated
Gene:
IL6
Gene Alias:
BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2, IFNB2, IL-6
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
3569
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid

Img

OriGene

50-167-1376

--

Antigen:
SERPINA1
Classification:
Monoclonal
Concentration:
__
Formulation:
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.:
P01009
Gene Symbols:
SERPINA1
Immunogen:
Human recombit protein fragment corresponding to amino acids 26-418 of human A1AT produced in E.coli.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG2b
Applications:
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Clone:
OTI1C2
Conjugate:
Unconjugated
Gene:
SERPINA1
Gene Alias:
A1A, A1AT, AAT, PI, PI1, PRO2275, alpha1AT, nNIF
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
5265
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid