50-167-57
FOXP3 Monoclonal Antibody (236A/E7), Alexa Fluor™ 488, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-167-57-Each-of-1 | In Stock | ₹ 34,480.68 |
50-167-57 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 34,480.68
GST (18%): ₹ 6,206.522
Total Price: ₹ 40,687.202
Antigen
FOXP3
Classification
Monoclonal
Concentration
5 μL/Test
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.
Q9BZS1
Gene Symbols
Foxp3
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
50943, 574303
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
Clone
236A/E7
Conjugate
Alexa Fluor 488
Gene
Foxp3
Gene Alias
AIID; DIETER; forkhead box P3; forkhead box protein P3; Forkhead box protein P3 41 kDa form; Forkhead box protein P3, C-terminally processed; forkhead/winged helix transcription factor 3; Foxp3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; IPEX; JM2; MGC141961; MGC141963; PIDX; regulatory protein Foxp3; RGD1562112; RP23-54C14.1; scurfin; scurfy; sf; XPID
Host Species
Mouse
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Human, Non-human Primate, Rhesus Monkey
Product Type
Antibody
Isotype
IgG1 κ
Related Products
Description
- Description: The 236A/E7 antibody reacts with human Foxp3 protein also known as FORKHEAD BOX P3, SCURFIN, and JM2
- Foxp3, a 49-55 kDa protein, is a member of the forkhead/winged-helix family of transcriptional regulators, and was identified as the gene defective in 'scurfy' (sf) mice
- Constitutive high expression of Foxp3 mRNA has been shown in CD4+CD25+ regulatory T cells (Treg cells), and ectopic expression of Foxp3 in CD4+CD25- cells imparts a Treg phenotype in these cells
- Intracellular staining and flow cytometric analysis of freshly isolated human peripheral blood mononuclear cells (PBMCs) with the 236A/E7 antibody using the Foxp3/Transcription Factor Staining Buffer Set (cat
- 00-5523) and protocol reveals staining of the CD4+CD25bright population
- The epitope from 236A/E7 is different from that of PCH101 (cat
- 72-5776)
- This antibody has also been shown to recognize rhesus macaque, sooty mangabey and cynomolgus macaque
- Applications Reported: This 236A/E7 antibody has been reported for use in intracellular staining followed by flow cytometric analysis and IHC
- Applications Tested: This 236A/E7 antibody has been pre-titrated and tested using the Foxp3/Transctiption Factor Staining Buffer Set (cat
- 00-5523) and protocol
- Please see Best Protocols Section (Staining intracellular Antigens for Flow Cytometry) for staining protocol (refer to Protocol B: One-step protocol for intracellular (nuclear) proteins)
- This can be used at 5 μL (0
- FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis
- FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells
- FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells
- Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice
- In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome
- Transcript variants of FOXP3 encoding different isoforms have been identified
- In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.
Compare Similar Items
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Antigen: FOXP3
Classification: Monoclonal
Concentration: 5 μL/Test
Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.: Q9BZS1
Gene Symbols: Foxp3
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 50943, 574303
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
Clone: 236A/E7
Conjugate: Alexa Fluor 488
Gene: Foxp3
Gene Alias: AIID; DIETER; forkhead box P3; forkhead box protein P3; Forkhead box protein P3 41 kDa form; Forkhead box protein P3, C-terminally processed; forkhead/winged helix transcription factor 3; Foxp3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; IPEX; JM2; MGC141961; MGC141963; PIDX; regulatory protein Foxp3; RGD1562112; RP23-54C14.1; scurfin; scurfy; sf; XPID
Host Species: Mouse
Quantity: 100 Tests
Primary or Secondary: Primary
Target Species: Human, Non-human Primate, Rhesus Monkey
Product Type: Antibody
Isotype: IgG1 κ
Antigen:
FOXP3
Classification:
Monoclonal
Concentration:
5 μL/Test
Formulation:
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.:
Q9BZS1
Gene Symbols:
Foxp3
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
50943, 574303
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Applications:
Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
Clone:
236A/E7
Conjugate:
Alexa Fluor 488
Gene:
Foxp3
Gene Alias:
AIID; DIETER; forkhead box P3; forkhead box protein P3; Forkhead box protein P3 41 kDa form; Forkhead box protein P3, C-terminally processed; forkhead/winged helix transcription factor 3; Foxp3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; IPEX; JM2; MGC141961; MGC141963; PIDX; regulatory protein Foxp3; RGD1562112; RP23-54C14.1; scurfin; scurfy; sf; XPID
Host Species:
Mouse
Quantity:
100 Tests
Primary or Secondary:
Primary
Target Species:
Human, Non-human Primate, Rhesus Monkey
Product Type:
Antibody
Isotype:
IgG1 κ
Antigen: PROSC
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.: O94903
Gene Symbols: PLPBP
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 11212
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Clone: OTI1G2
Conjugate: Unconjugated
Gene: PLPBP
Gene Alias: EPVB6D, PROSC
Host Species: Mouse
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Antigen:
PROSC
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.:
O94903
Gene Symbols:
PLPBP
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
11212
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Clone:
OTI1G2
Conjugate:
Unconjugated
Gene:
PLPBP
Gene Alias:
EPVB6D, PROSC
Host Species:
Mouse
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Antigen: PROSC
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.: O94903
Gene Symbols: PLPBP
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 11212
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Clone: OTI3A6
Conjugate: Unconjugated
Gene: PLPBP
Gene Alias: EPVB6D, PROSC
Host Species: Mouse
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Antigen:
PROSC
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.:
O94903
Gene Symbols:
PLPBP
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
11212
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Clone:
OTI3A6
Conjugate:
Unconjugated
Gene:
PLPBP
Gene Alias:
EPVB6D, PROSC
Host Species:
Mouse
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Antigen: CDKN2B
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.: P42772
Gene Symbols: CDKN2B
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 1030
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Flow Cytometry, Western Blot
Clone: OTI3E4
Conjugate: Unconjugated
Gene: CDKN2B
Gene Alias: CDK4I, INK4B, MTS2, P15, TP15, p15INK4b
Host Species: Mouse
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Antigen:
CDKN2B
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.:
P42772
Gene Symbols:
CDKN2B
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
1030
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Flow Cytometry, Western Blot
Clone:
OTI3E4
Conjugate:
Unconjugated
Gene:
CDKN2B
Gene Alias:
CDK4I, INK4B, MTS2, P15, TP15, p15INK4b
Host Species:
Mouse
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1