50-168-4407
ARC Monoclonal Antibody (OTI2B3), TrueMAB™, OriGene
Manufacturer: OriGene
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-168-4407-Each-of-1 | In Stock | ₹ 43,217.21 |
50-168-4407 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 43,217.21
GST (18%): ₹ 7,779.098
Total Price: ₹ 50,996.308
Antigen
ARC
Classification
Monoclonal
Conjugate
Unconjugated
Gene
ARC
Gene Alias
Arg3.1
Host Species
Mouse
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
23237
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Clone
OTI2B3
Formulation
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.
Q7LC44
Gene Symbols
ARC
Immunogen
Human recombit protein fragment corresponding to amino acids 100-396 of human ARC produced in E.coli.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2b
Description
- Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system
- ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation
- ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons
- Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory
- Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis
- Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses
- Accumulates at weaker synapses, probably to prevent their undesired enhancement
- This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material
- Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory
- Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1
- In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation.
Compare Similar Items
Show Difference
Antigen: ARC
Classification: Monoclonal
Conjugate: Unconjugated
Gene: ARC
Gene Alias: Arg3.1
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 23237
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Clone: OTI2B3
Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.: Q7LC44
Gene Symbols: ARC
Immunogen: Human recombit protein fragment corresponding to amino acids 100-396 of human ARC produced in E.coli.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG2b
Antigen:
ARC
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene:
ARC
Gene Alias:
Arg3.1
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
23237
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Clone:
OTI2B3
Formulation:
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.:
Q7LC44
Gene Symbols:
ARC
Immunogen:
Human recombit protein fragment corresponding to amino acids 100-396 of human ARC produced in E.coli.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG2b
Antigen: ARC
Classification: Monoclonal
Conjugate: Unconjugated
Gene: ARC
Gene Alias: Arg3.1
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 23237
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Clone: OTI2H7
Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.: Q7LC44
Gene Symbols: ARC
Immunogen: Human recombit protein fragment corresponding to amino acids 100-396 of human ARC produced in E.coli.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Antigen:
ARC
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene:
ARC
Gene Alias:
Arg3.1
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
23237
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Clone:
OTI2H7
Formulation:
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.:
Q7LC44
Gene Symbols:
ARC
Immunogen:
Human recombit protein fragment corresponding to amino acids 100-396 of human ARC produced in E.coli.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Antigen: ATP2A2
Classification: Monoclonal
Conjugate: Unconjugated
Gene: ATP2A2
Gene Alias: ATP2B, DAR, DD, SERCA2
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 488
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Clone: OTI4B12
Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.: P16615
Gene Symbols: ATP2A2
Immunogen: Human recombit protein fragment corresponding to amino acids 314-756 of human ATP2A2 produced in E.coli.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Antigen:
ATP2A2
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene:
ATP2A2
Gene Alias:
ATP2B, DAR, DD, SERCA2
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
488
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Clone:
OTI4B12
Formulation:
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.:
P16615
Gene Symbols:
ATP2A2
Immunogen:
Human recombit protein fragment corresponding to amino acids 314-756 of human ATP2A2 produced in E.coli.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Antigen: COX17
Classification: Monoclonal
Conjugate: Unconjugated
Gene: COX17
Gene Alias: COX17, cytochrome c oxidase copper chaperone
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 10063
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Clone: OTI1C2
Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.: Q14061
Gene Symbols: COX17
Immunogen: Human recombit protein fragment corresponding to amino acids 2-63 of human COX17 produced in E.coli.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Antigen:
COX17
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene:
COX17
Gene Alias:
COX17, cytochrome c oxidase copper chaperone
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
10063
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Clone:
OTI1C2
Formulation:
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.:
Q14061
Gene Symbols:
COX17
Immunogen:
Human recombit protein fragment corresponding to amino acids 2-63 of human COX17 produced in E.coli.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1