50-173-6933
MDM2 Mouse anti-Human, Mouse, Rat, Clone: 2A6C9, Proteintech
Manufacturer: Proteintech Group Inc
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-173-6933-Each-of-1 | In Stock | ₹ 44,150.23 |
50-173-6933 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,150.23
GST (18%): ₹ 7,947.041
Total Price: ₹ 52,097.271
Antigen
MDM2
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene Accession No.
P23804, Q00987
Gene Symbols
Mdm2
Immunogen
Peptide
Quantity
150 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG2b
Applications
Western Blot
Clone
2A6C9
Conjugate
Unconjugated
Gene
MDM2
Gene Alias
Double minute 2 protein, hdm2, HDMX, MDM2, Oncoprotein Mdm2, p53 binding protein Mdm2
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
17246, 314856, 4193
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- MDM2 is a ubiquitin ligase for p53 and plays a central role in regulation of the stability of p53
- MDM2 is located on chromosome 12 on the q arm
- Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53
- Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53
- MDM2 has also been shown to negatively regulate p53 function
- MDM2 binds and inhibits transactivation role played by p53 and overexpression of MDM2 can result in the inactivation of p53 and decrease its tumor suppressor function
- Another process by which MDM2 can inactivate p53 is by degrading p53 as the protein also possesses E3 ubiquitin ligase activity
- Further, MDM2 plays important roles in apoptosis and cell cycle
- MDM2 is over expressed in a wide range of human maligcies including soft tissue carcinomas and breast cancer
- In addition to p53, MDM2 is involved in processes of cell cycle, apoptosis, and tumorigenesis through interactions with proteins that include retinoblastoma 1 and ribosomal protein L5
- More than 40 different alternatively spliced transcript variants of MDM2 have been isolated from both tumor and normal tissues.
Compare Similar Items
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Antigen: MDM2
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene Accession No.: P23804, Q00987
Gene Symbols: Mdm2
Immunogen: Peptide
Quantity: 150 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG2b
Applications: Western Blot
Clone: 2A6C9
Conjugate: Unconjugated
Gene: MDM2
Gene Alias: Double minute 2 protein, hdm2, HDMX, MDM2, Oncoprotein Mdm2, p53 binding protein Mdm2
Host Species: Mouse
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 17246, 314856, 4193
Content And Storage: -20°C
Form: Liquid
Antigen:
MDM2
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene Accession No.:
P23804, Q00987
Gene Symbols:
Mdm2
Immunogen:
Peptide
Quantity:
150 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG2b
Applications:
Western Blot
Clone:
2A6C9
Conjugate:
Unconjugated
Gene:
MDM2
Gene Alias:
Double minute 2 protein, hdm2, HDMX, MDM2, Oncoprotein Mdm2, p53 binding protein Mdm2
Host Species:
Mouse
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
17246, 314856, 4193
Content And Storage:
-20°C
Form:
Liquid
Antigen: ING2
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene Accession No.: Q9ESK4, Q9H160
Gene Symbols: Ing2
Immunogen: ING2 Fusion Protein Ag19291
Quantity: 150 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG1
Applications: Western Blot
Clone: 2C3A7
Conjugate: Unconjugated
Gene: ING2
Gene Alias: ING1L, ING1Lp, ING2, Inhibitor of growth protein 2, p32, p33ING2
Host Species: Mouse
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 290744, 3622, 69260
Content And Storage: -20°C
Form: Liquid
Antigen:
ING2
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene Accession No.:
Q9ESK4, Q9H160
Gene Symbols:
Ing2
Immunogen:
ING2 Fusion Protein Ag19291
Quantity:
150 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG1
Applications:
Western Blot
Clone:
2C3A7
Conjugate:
Unconjugated
Gene:
ING2
Gene Alias:
ING1L, ING1Lp, ING2, Inhibitor of growth protein 2, p32, p33ING2
Host Species:
Mouse
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
290744, 3622, 69260
Content And Storage:
-20°C
Form:
Liquid
Antigen: USP7
Classification: Monoclonal
Concentration: 0.77 mg/mL
Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene Accession No.: Q4VSI4, Q6A4J8, Q93009
Gene Symbols: Usp7
Immunogen: USP7 Fusion Protein Ag25652
Quantity: 150 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG2a
Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Clone: 3D7D11
Conjugate: Unconjugated
Gene: USP7
Gene Alias: Deubiquitinating enzyme 7, HAUSP, TEF1, Ubiquitin thioesterase 7, USP7
Host Species: Mouse
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 252870, 360471, 7874
Content And Storage: -20°C
Form: Liquid
Antigen:
USP7
Classification:
Monoclonal
Concentration:
0.77 mg/mL
Formulation:
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene Accession No.:
Q4VSI4, Q6A4J8, Q93009
Gene Symbols:
Usp7
Immunogen:
USP7 Fusion Protein Ag25652
Quantity:
150 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG2a
Applications:
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Clone:
3D7D11
Conjugate:
Unconjugated
Gene:
USP7
Gene Alias:
Deubiquitinating enzyme 7, HAUSP, TEF1, Ubiquitin thioesterase 7, USP7
Host Species:
Mouse
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
252870, 360471, 7874
Content And Storage:
-20°C
Form:
Liquid
Antigen: SMAD3
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene Accession No.: P84022, Q8BUN5
Gene Symbols: Smad3
Immunogen: Peptide
Quantity: 150 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG1
Applications: Western Blot
Clone: 1F10B2
Conjugate: Unconjugated
Gene: SMAD3
Gene Alias: hMAD 3, hSMAD3, HSPC193, HsT17436, JV15 2, MAD homolog 3, Mad3, MADH3, Mothers against DPP homolog 3, SMAD 3, SMAD family member 3, SMAD3
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 17127, 4088
Content And Storage: -20°C
Form: Liquid
Antigen:
SMAD3
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene Accession No.:
P84022, Q8BUN5
Gene Symbols:
Smad3
Immunogen:
Peptide
Quantity:
150 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG1
Applications:
Western Blot
Clone:
1F10B2
Conjugate:
Unconjugated
Gene:
SMAD3
Gene Alias:
hMAD 3, hSMAD3, HSPC193, HsT17436, JV15 2, MAD homolog 3, Mad3, MADH3, Mothers against DPP homolog 3, SMAD 3, SMAD family member 3, SMAD3
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
17127, 4088
Content And Storage:
-20°C
Form:
Liquid