CD120a (TNF Receptor I) Monoclonal Antibody (H398), eBioscience™, Invitrogen™

Description

• Description: The monoclonal antibody H398 recognizes the extracellular part of the Tumor Necrosis Factor Receptor type I (TNF-RI) of the membrane-bound as well as the soluble receptor
• The monoclonal antibody H398 can be used for immuno assay, flow cytometry, immuno precipitation and Western blotting
• Furthermore, the monoclonal antibody H398 is useful for immunohistology on frozen sections
• The monoclonal antibody H398 is also useful as antagonistic antibody in functional studies
• Be aware that the antibody competes with TNF-alpha
• Applications Tested: Flow Cytometry, Functional Studies (Blocking), Immunohistochemistry (Frozen)
• Purity: >95%
• TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily, and is one of the major TNF-alpha receptors
• TNFR1 plays an important role in mediating, in cytokine mediated signaling, positive regulation of the NF-Kb pathway, positive regulation of angiogenesis, and negative regulation of gene expression
• The extracellular domain of TNFR1 is also released into the circulatory system as soluble TNFR1 (sTNFR1)
• In humans, the TNFR1 gene is located on chromosome 12
• Anti-apoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with TNFR1, and thus play regulatory roles in the signal transduction mediated by the receptor
• Germline mutations of the extracellular domains of TNFR1 were found to be associated with the autosomal dominant periodic fever syndrome, and the impaired receptor clearance is thought to be a mechanism of the disease.