Cathepsin L Monoclonal Antibody (33/1), FITC, eBioscience™, Invitrogen™

Description

• Description: Cathepsin L is a lysosomal cysteine proteinase consisting of a heavy chain of about 25 kDa and a light chain of about 5 kDa derived proteolytically from the same precursor
• Cathepsin L has been shown to be produced by many different cell types
• Since cathepsin L is capable of degrading protein constituents of the extracellular matrix it is assumed to play a crucial role in tumor progression and metastasis and a number of other disorders where the destruction of the extracellular matrix is the major cause of disease (e.g
• rheumatoid arthritis, neurodegeneration)
• Purity: >95%
• Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism
• Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity
• The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria
• This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor
• At least two transcript variants encoding the same protein have been found for this gene.