HCV Core protein Rabbit anti-Virus, Polyclonal, Bioss

Description

• Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding
• Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit
• Also regulates many host cellular functions such as signaling pathways and apoptosis
• Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation
• Plays an important role in virus-mediated cell transformation leading to hepatocellular carcinomas
• Interacts with, and activates STAT3 leading to cellular transformation
• May repress the promoter of p53, and sequester CREB3 and SP110 isoform3/Sp110b in the cytoplasm
• Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation
• Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, and activates AP-1
• Mediates apoptotic pathways throught association with TNF-type receptors TNFRSF1A and LTBR, although its effect on death receptors-induced apoptosis remains controvertial
• Enhances TRAIL mediated apoptosis, suggesting that it might play a role in mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury
• Secreted core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation
• May transactivate human MYC, Rous sarcoma virus LTR, and SV40 promoters
• May suppress the human FOS and HIV-1 LTR activity
• May alter lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage.