Measles Virus Fusion Protein Rabbit anti-Virus, Polyclonal, Bioss

Description

• Class I viral fusion protein
• Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state
• During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain
• The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes
• Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm
• This fusion is pH independent and occurs directly at the outer cell membrane
• The trimer of F1-F2 (F protein) probably interacts with H at the virion surface
• Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes
• Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis.