50-198-9544
Cyclin D1 Rabbit anti-Human, Clone: 2H4, Bioss
Manufacturer: Bioss
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-198-9544-Each-of-1 | In Stock | ₹ 47,374.57 |
50-198-9544 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,374.57
GST (18%): ₹ 8,527.423
Total Price: ₹ 55,901.993
Antigen
Cyclin D1
Classification
Monoclonal
Concentration
1 μg/mL
Formulation
TBS with 1% BSA, 40% glycerol and 0.05% sodium azide; pH
Gene Accession No.
P24385
Gene Symbols
CCND1
Immunogen
Recombinant human Cyclin D1 protein, around C-terminal 150aa.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
2H4
Conjugate
Unconjugated
Gene
CCND1
Gene Alias
AI327039; B-cell CLL/lymphoma 1; B-cell lymphoma 1 protein; BCL1; BCL-1; BCL-1 oncogene; CCND1; CCND1 protein; cD1; cDNA; CycD1; cyclin D1; Cyl-1; D11S287E; FLJ93625; G1/S-specific cyclin-D1; mRNA; PRAD1; PRAD-1; PRAD1 oncogene; U21B31
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
595
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- Cyclin D1 (PRAD-1, bcl-1) is one of the key cell cycle regulators, and functions in association with cdk4 and/or cdk6 by phosphorylating the Rb protein
- Cyclin D1 is a putative proto-oncogene overexpressed in a wide variety of human neoplasms including mantle cell lymphomas (MCL)
- In addition, cyclin D1 positively regulates protein phosphorylation, mammary gland epithelial cell proliferation, and fat cell differentiation
- In humans, the CCND1 gene encoding cyclin D1 is present on chromosome 11
- Cyclin D1 is a cytoplasmic and nuclear protein that is synthesized during G1 phase and assembles with either cyclin-dependent kinase 4 (CDK4) or CDK6 in response to growth factor stimulation
- D-type cyclin-CDK complexes act to inactivate the growth-suppressive function of the Rb protein through its phosphorylation, and titrate CDK inhibitors such as p21Cip1 and p27Kip1
- Without growth factor-mediated stimulation, Cyclin D1 is unstable, and undergoes ubiquitin-mediated degradation, which is triggered by its phosphorylation
- Cyclin D1 destabilization participates in G1/S phase arrest
- The Cyclin D1 protein belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle
- Cyclins function as regulators of CDK kinases
- Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event
- Cyclin D1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition
- The Cyclin D1 protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb
- Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis
- Cyclin D1 has been successfully employed and is a promising tool for further studies in both cell cycle biology and cancer associated abnormalities.
Compare Similar Items
Show Difference
Antigen: Cyclin D1
Classification: Monoclonal
Concentration: 1 μg/mL
Formulation: TBS with 1% BSA, 40% glycerol and 0.05% sodium azide; pH
Gene Accession No.: P24385
Gene Symbols: CCND1
Immunogen: Recombinant human Cyclin D1 protein, around C-terminal 150aa.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: 2H4
Conjugate: Unconjugated
Gene: CCND1
Gene Alias: AI327039; B-cell CLL/lymphoma 1; B-cell lymphoma 1 protein; BCL1; BCL-1; BCL-1 oncogene; CCND1; CCND1 protein; cD1; cDNA; CycD1; cyclin D1; Cyl-1; D11S287E; FLJ93625; G1/S-specific cyclin-D1; mRNA; PRAD1; PRAD-1; PRAD1 oncogene; U21B31
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 595
Content And Storage: -20°C
Form: Liquid
Antigen:
Cyclin D1
Classification:
Monoclonal
Concentration:
1 μg/mL
Formulation:
TBS with 1% BSA, 40% glycerol and 0.05% sodium azide; pH
Gene Accession No.:
P24385
Gene Symbols:
CCND1
Immunogen:
Recombinant human Cyclin D1 protein, around C-terminal 150aa.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
2H4
Conjugate:
Unconjugated
Gene:
CCND1
Gene Alias:
AI327039; B-cell CLL/lymphoma 1; B-cell lymphoma 1 protein; BCL1; BCL-1; BCL-1 oncogene; CCND1; CCND1 protein; cD1; cDNA; CycD1; cyclin D1; Cyl-1; D11S287E; FLJ93625; G1/S-specific cyclin-D1; mRNA; PRAD1; PRAD-1; PRAD1 oncogene; U21B31
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
595
Content And Storage:
-20°C
Form:
Liquid
Antigen: Cyclin D3
Classification: Monoclonal
Concentration: 1 μg/mL
Formulation: TBS with 1% BSA, 40% glycerol and 0.05% sodium azide; pH
Gene Accession No.: P30281
Gene Symbols: CCND3
Immunogen: Recombinant human Cyclin D3 protein, around C-terminal 200aa.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Immunofluorescence, Western Blot
Clone: 4A8
Conjugate: Unconjugated
Gene: CCND3
Gene Alias: 9230106B05Rik; AA682053; AL024085; AW146355; C78795; CCND 3; CCND3; CGD3; cyclin D3; CyclinD3; Cyl-3; D3 type cyclin; D3-type cyclin; G1/S-specific cyclin-D3; OTTHUMP00000223415; RP5-973N23.3
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 896
Content And Storage: -20°C
Form: Liquid
Antigen:
Cyclin D3
Classification:
Monoclonal
Concentration:
1 μg/mL
Formulation:
TBS with 1% BSA, 40% glycerol and 0.05% sodium azide; pH
Gene Accession No.:
P30281
Gene Symbols:
CCND3
Immunogen:
Recombinant human Cyclin D3 protein, around C-terminal 200aa.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunofluorescence, Western Blot
Clone:
4A8
Conjugate:
Unconjugated
Gene:
CCND3
Gene Alias:
9230106B05Rik; AA682053; AL024085; AW146355; C78795; CCND 3; CCND3; CGD3; cyclin D3; CyclinD3; Cyl-3; D3 type cyclin; D3-type cyclin; G1/S-specific cyclin-D3; OTTHUMP00000223415; RP5-973N23.3
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
896
Content And Storage:
-20°C
Form:
Liquid
Antigen: Cytochrome C
Classification: Monoclonal
Concentration: 1 μg/mL
Formulation: TBS with 1% BSA, 40% glycerol and 0.05% sodium azide; pH
Gene Accession No.: P99999
Gene Symbols: Cycs
Immunogen: Recombinant human Cytochrome C protein, full length.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Immunofluorescence, Immunohistochemistry (Paraffin)
Clone: 1F10
Conjugate: Unconjugated
Gene: Cycs
Gene Alias: BOS_4320; CG17903; CG17903 gene product from transcript CG17903-RA; CG17903-PA; CG17903-PB; CRF; CYC; CYCS; CYCSA; Cyct-c-p; Cyt c; cyt c-p; cyt.c; CytC; CYTC2; cyt-c2; CytC-2; Cyt-c-p; Cytc-p; Cyt-c-p-PA; Cyt-c-p-PB; Cytochrome c; cytochrome c DC4; cytochrome c proximal; Cytochrome C, expressed in somatic tissues; Cytochrome c, somatic; cytochrome c, somatic-like; Cytochrome c-2; cytochrome c-like protein; Cytochrome c-proximal; cytochrome-c-p; Cytochrome-c-proximal; DC4; dCyt.C-p; DMc01; Dmel\CG17903; Dmel_CG17903; HCS; LOC100341175; LOC100357840; pDMc01; THC4
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 54205
Content And Storage: -20°C
Form: Liquid
Antigen:
Cytochrome C
Classification:
Monoclonal
Concentration:
1 μg/mL
Formulation:
TBS with 1% BSA, 40% glycerol and 0.05% sodium azide; pH
Gene Accession No.:
P99999
Gene Symbols:
Cycs
Immunogen:
Recombinant human Cytochrome C protein, full length.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunofluorescence, Immunohistochemistry (Paraffin)
Clone:
1F10
Conjugate:
Unconjugated
Gene:
Cycs
Gene Alias:
BOS_4320; CG17903; CG17903 gene product from transcript CG17903-RA; CG17903-PA; CG17903-PB; CRF; CYC; CYCS; CYCSA; Cyct-c-p; Cyt c; cyt c-p; cyt.c; CytC; CYTC2; cyt-c2; CytC-2; Cyt-c-p; Cytc-p; Cyt-c-p-PA; Cyt-c-p-PB; Cytochrome c; cytochrome c DC4; cytochrome c proximal; Cytochrome C, expressed in somatic tissues; Cytochrome c, somatic; cytochrome c, somatic-like; Cytochrome c-2; cytochrome c-like protein; Cytochrome c-proximal; cytochrome-c-p; Cytochrome-c-proximal; DC4; dCyt.C-p; DMc01; Dmel\CG17903; Dmel_CG17903; HCS; LOC100341175; LOC100357840; pDMc01; THC4
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
54205
Content And Storage:
-20°C
Form:
Liquid
Antigen: Cytokeratin 1
Classification: Monoclonal
Concentration: 1 μg/mL
Formulation: TBS with 1% BSA, 40% glycerol and 0.05% sodium azide; pH
Gene Accession No.: P04264
Gene Symbols: KRT1
Immunogen: Recombinant human Cytokeratin 1 protein, around C-terminal 100aa.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: 1C2
Conjugate: Unconjugated
Gene: KRT1
Gene Alias: 67 kDa cytokeratin; CK1; CK-1; cytokeratin 1; Cytokeratin-1; EHK; EHK1; epidermolytic hyperkeratosis 1; epithelial keratin 1; Epithelial keratin-1; EPPK; Hair alpha protein; HMWCK; K1; Kb1; KER1; keratin 1; keratin 1 (epidermolytic hyperkeratosis); keratin 1, type II; keratin 6A-like; keratin 86; keratin complex 2, basic, gene 1; Keratin, type II cytoskeletal 1; Keratin-1; KRT1; krt1 {ECO:0000250; KRT1A; Krt-2.1; Krt2-1; Krt86; KRTA; LOC100353415; NEPPK; type II keratin Kb1; Type-II keratin Kb1; UniProtKB:P04264}
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 3848
Content And Storage: -20°C
Form: Liquid
Antigen:
Cytokeratin 1
Classification:
Monoclonal
Concentration:
1 μg/mL
Formulation:
TBS with 1% BSA, 40% glycerol and 0.05% sodium azide; pH
Gene Accession No.:
P04264
Gene Symbols:
KRT1
Immunogen:
Recombinant human Cytokeratin 1 protein, around C-terminal 100aa.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
1C2
Conjugate:
Unconjugated
Gene:
KRT1
Gene Alias:
67 kDa cytokeratin; CK1; CK-1; cytokeratin 1; Cytokeratin-1; EHK; EHK1; epidermolytic hyperkeratosis 1; epithelial keratin 1; Epithelial keratin-1; EPPK; Hair alpha protein; HMWCK; K1; Kb1; KER1; keratin 1; keratin 1 (epidermolytic hyperkeratosis); keratin 1, type II; keratin 6A-like; keratin 86; keratin complex 2, basic, gene 1; Keratin, type II cytoskeletal 1; Keratin-1; KRT1; krt1 {ECO:0000250; KRT1A; Krt-2.1; Krt2-1; Krt86; KRTA; LOC100353415; NEPPK; type II keratin Kb1; Type-II keratin Kb1; UniProtKB:P04264}
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
3848
Content And Storage:
-20°C
Form:
Liquid