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50-199-1579

GRK2 Polyclonal Antibody, Rockland™

Manufacturer: Fischer Scientific

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Pack Size SKU Availability Price
Each of 1 50-199-1579-Each-of-1 In Stock ₹ 50,884.24

50-199-1579 - Each of 1

₹ 50,884.24

In Stock

Quantity

1

Base Price: ₹ 50,884.24

GST (18%): ₹ 9,159.163

Total Price: ₹ 60,043.403

Antigen

GRK2

Classification

Polyclonal

Conjugate

Unconjugated

Gene

GRK2

Gene Alias

Adrbk1; Adrbk-1; adrenergic beta receptor kinase 1; adrenergic receptor kinase, beta 1; adrenergic, beta, receptor kinase 1; BARK; BARK1; Bark-1; beta ARK; Beta-adrenergic receptor kinase 1; beta-adrenergic receptor kinase 1 beta ARK1; beta-AR kinase-1; betaARK1; BETA-ARK1; Beta-ARK-1; EC 2.7.1.126; G protein-coupled receptor kinase 2; G-protein coupled receptor kinase 2; G-protein-coupled receptor kinase 2; GRK2; GRK-2

Host Species

Goat

Regulatory Status

RUO

Gene ID (Entrez)

110355, 156

Content And Storage

-20°C, Avoid Freeze/Thaw Cycles

Form

Liquid

Applications

ELISA, Immunofluorescence, Immunohistochemistry, Western Blot

Concentration

0.89 mg/mL

Formulation

0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2

Gene Accession No.

P25098, Q99MK8

Gene Symbols

GRK2

Quantity

100 μg

Primary or Secondary

Primary

Target Species

Human, Mouse

Product Type

Antibody

Description

  • Store vial at -20°C prior to opening
  • Aliquot contents and freeze at -20°C or below for extended storage
  • Avoid cycles of freezing and thawing
  • Centrifuge product if not completely clear after standing at room temperature
  • This product is stable for several weeks at 4°C as an undiluted liquid
  • Dilute only prior to immediate use
  • This affinity purified antibody is directed against human GRK2
  • A BLAST analysis of the sequence shows 100% reactivity to human, and 90% to rat, mouse, and golden hamster
  • G protein-coupled receptor kinases (GRKs) are important regulators of G protein-coupled receptors(GPCRs)
  • GRK2 (83 kDa), one of six members of this family that have been identified, is ubiquitously expressed in mammals
  • After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs (e.g., ?2-adrenergic receptor) are phosphorylated by GRKs
  • Internalization of the GPCRs ,regulated by beta-arrestin-1, leads to activation of the Ras - Raf - ERK1&2 signaling pathway
  • GRK2 activity is tightly controlled by different mechanisms including phosphorylation by kinases such as PKC, Src and ERK1&2, as well as interaction with various proteins
  • ERK phosphorylates and thus inactivates GRK2 on serine 670 in a negative feedback mechanism.

Compare Similar Items

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Fischer Scientific

50-199-1579

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Antigen:
GRK2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
GRK2
Gene Alias:
Adrbk1; Adrbk-1; adrenergic beta receptor kinase 1; adrenergic receptor kinase, beta 1; adrenergic, beta, receptor kinase 1; BARK; BARK1; Bark-1; beta ARK; Beta-adrenergic receptor kinase 1; beta-adrenergic receptor kinase 1 beta ARK1; beta-AR kinase-1; betaARK1; BETA-ARK1; Beta-ARK-1; EC 2.7.1.126; G protein-coupled receptor kinase 2; G-protein coupled receptor kinase 2; G-protein-coupled receptor kinase 2; GRK2; GRK-2
Host Species:
Goat
Regulatory Status:
RUO
Gene ID (Entrez):
110355, 156
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
Concentration:
0.89 mg/mL
Formulation:
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.:
P25098, Q99MK8
Gene Symbols:
GRK2
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody

Img

Bioworld

50-199-158

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Antigen:
__
Classification:
__
Conjugate:
__
Gene:
__
Gene Alias:
__
Host Species:
__
Regulatory Status:
__
Gene ID (Entrez):
__
Content And Storage:
__
Form:
__
Applications:
__
Concentration:
__
Formulation:
__
Gene Accession No.:
__
Gene Symbols:
__
Quantity:
__
Primary or Secondary:
__
Target Species:
__
Product Type:
__

Img

Fischer Scientific

50-199-1580

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Antigen:
GRK2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
GRK2
Gene Alias:
Adrbk1; Adrbk-1; adrenergic beta receptor kinase 1; adrenergic receptor kinase, beta 1; adrenergic, beta, receptor kinase 1; BARK; BARK1; Bark-1; beta ARK; Beta-adrenergic receptor kinase 1; beta-adrenergic receptor kinase 1 beta ARK1; beta-AR kinase-1; betaARK1; BETA-ARK1; Beta-ARK-1; EC 2.7.1.126; G protein-coupled receptor kinase 2; G-protein coupled receptor kinase 2; G-protein-coupled receptor kinase 2; GRK2; GRK-2
Host Species:
Goat
Regulatory Status:
RUO
Gene ID (Entrez):
110355, 156
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
Concentration:
0.89 mg/mL
Formulation:
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.:
P25098, Q99MK8
Gene Symbols:
GRK2
Quantity:
25 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody

Img

Fischer Scientific

50-199-1581

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Antigen:
Doublecortin
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
DCX
Gene Alias:
BOS_25702; DBCN; Dbct; DC; Dcn; Dcx; doublecortex; doublecortin; Doublin; Lissencephalin-X; lissencephaly, X-linked (doublecortin); LISX; Lis-X; LIS-XD; Neuronal migration protein doublecortin; OTTHUMP00000023860; OTTHUMP00000216316; SCLH; XLIS
Host Species:
Goat
Regulatory Status:
RUO
Gene ID (Entrez):
13193, 1641, 84394
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
Concentration:
0.79 mg/mL
Formulation:
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.:
O43602, O88809, Q9ESI7
Gene Symbols:
DCX
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody